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B.M. Fontes, R. Belfort, Jr, A. Romano, C. Muccioli, A. Höfling-Lima; Conjunctival Flora in Patients Under Prolonged Use of Antibiotics: Ciprofloxacin X Tobramycin . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4892.
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Purpose: To evaluate conjunctival flora and investigate bacterial resistance of patients in prolonged use of topical dexamethasone associated with tobramycin or ciprofloxacin. Methods: Cross–sectional study, with clinical and experimental laboratory investigation. Conjunctival samples from patients under topical treatment for 4 or more weeks were submitted to cultures in order to determine conjunctival flora and test antibiotic susceptibility. Results: A total of 18 patients (18 eyes) were randomly divided in two groups, regarding the antibiotic in use: Group 1 – Tobramycin (7 eyes), and Group 2 – Ciprofloxacin (11 eyes). All cultures were positive in Group 1 (100%) and in 8 eyes (73%) in Group 2. Coagulase–negative Staphylococcus was the most common bacteria isolated (13 eyes). Prevalence of resistant bacteria to antibiotic in use was higher in Group 1 (83%) than in Group 2 (44%). Conclusions: We found positive cultures in most samples, and a higher prevalence of bacterial resistance in tobramycin group, when compared to ciprofloxacin group.
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