May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Scanning Electron Microscopic Findings of the Flap From Exacerbated Avellino Corneal Dystrophy
E.–K. Kim; M.I. Roh; S.–H. Chung; H.E. Grossniklaus; S.J. Kang; W.C. Kim; S.Y. Choi
Author Affiliations & Notes
  • E.–K. Kim
    Ophthalmology, Yonsei University, Institute of vision research, Seoul, Republic of Korea
  • M.I. Roh
    Ophthalmology, Yonsei University, Institute of Vision Research, Seoul, Republic of Korea
  • S.–H. Chung
    Ophthalmology, Yonsei University, Institute of Vision Research, Seoul, Republic of Korea
  • H.E. Grossniklaus
    Ophthalmology,
    Emory University, Atlanta, GA
  • S.J. Kang
    Ophthalmology,
    Emory University, Atlanta, GA
  • W.C. Kim
    Emory University, Atlanta, GA
  • S.Y. Choi
    Ophthalmology, Yonsei University, Institute of Vision Research, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  E. Kim, None; M.I. Roh, None; S. Chung, None; H.E. Grossniklaus, None; S.J. Kang, None; W.C. Kim, None; S.Y. Choi, None.
  • Footnotes
    Support  Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea. (02–PJ1–PG1–CH02–0003)
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 4920. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Scanning Electron Microscopic Findings of the Flap From Exacerbated Avellino Corneal Dystrophy
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      E.–K. Kim, M.I. Roh, S.–H. Chung, H.E. Grossniklaus, S.J. Kang, W.C. Kim, S.Y. Choi; Scanning Electron Microscopic Findings of the Flap From Exacerbated Avellino Corneal Dystrophy . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4920.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Abstract: : Purpose: To introduce new pathological findings showing the pathogenesis of Avellino corneal dystrophy (ACD) Methods: Three heterozygote ACD eyes showing numerous recently accumulated granules at the interface after LASIK and three normal eyes after LASIK were enrolled. Scanning electron microscopy was performed on the stromal surface of the removed LASIK flaps. Results: In all eyes, breaks of collagen bundles were observed at stromal side of flap. In ACD eyes, abundant abnormally clumped materials were observed at the stromal surface of the flap attached to collagen fibers, while there was no crystallized material in flaps of normal eyes. Conclusions: The R124H mutated gene in ACD would induce production of abnormal material by keratocyte during repair of damaged collagen.

Keywords: pathology: human • cornea: clinical science • refractive surgery: complications 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept