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E.–K. Kim, M.I. Roh, S.–H. Chung, H.E. Grossniklaus, S.J. Kang, W.C. Kim, S.Y. Choi; Scanning Electron Microscopic Findings of the Flap From Exacerbated Avellino Corneal Dystrophy . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4920.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To introduce new pathological findings showing the pathogenesis of Avellino corneal dystrophy (ACD) Methods: Three heterozygote ACD eyes showing numerous recently accumulated granules at the interface after LASIK and three normal eyes after LASIK were enrolled. Scanning electron microscopy was performed on the stromal surface of the removed LASIK flaps. Results: In all eyes, breaks of collagen bundles were observed at stromal side of flap. In ACD eyes, abundant abnormally clumped materials were observed at the stromal surface of the flap attached to collagen fibers, while there was no crystallized material in flaps of normal eyes. Conclusions: The R124H mutated gene in ACD would induce production of abnormal material by keratocyte during repair of damaged collagen.
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