May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Higher Order Wavefront Aberrations in Early Keratoconus and Keratoconus Suspects
Author Affiliations & Notes
  • B. Jafri
    Cornea Genetic Eye Inst,
    Cedars Sinai Medical Center, Los Angeles, CA
  • X. Li
    Division of Medical Genetics,
    Cedars Sinai Medical Center, Los Angeles, CA
  • H. Yang
    Division of Medical Genetics,
    Cedars Sinai Medical Center, Los Angeles, CA
  • Y.S. Rabinowitz
    Cornea Genetic Eye Inst,
    Cedars Sinai Medical Center, Los Angeles, CA
  • Footnotes
    Commercial Relationships  B. Jafri, None; X. Li, None; H. Yang, None; Y.S. Rabinowitz, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 4951. doi:
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    • Get Citation

      B. Jafri, X. Li, H. Yang, Y.S. Rabinowitz; Higher Order Wavefront Aberrations in Early Keratoconus and Keratoconus Suspects . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4951.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Abstract:
 

To determine whether higher order aberrations detected with the ALCON

 

LADARWAVE wavefront sensor can be used to distinguish ‘early’ keratoconus and

 

keratoconus ‘suspects’ from a normal control group.

 

We studied 52 normal controls, 12 patients with ‘early’ keratoconus and 11 keratoconus ‘suspects’ with videokeratography (TMS–1, Tomey) and aberrometry (LADARWAVE,Alcon). Videokeratography patterns and Zernike polynomials were analyzed for each patient. Data were compared and analyzed to determine whether specific higher order aberrations could be identified to separate ‘early’ keratoconus and keratoconus ‘suspects’ from normal controls.

 

see Table

 

 

*: F–test for data with normal distribution; Wilcoxon test for data without normal distribution.

 

Vertical coma, secondary astigmatism, and total RMS coma appear to be useful in distinguishing ‘early’ keratoconus and keratoconus ‘suspects’ from normal controls. Vertical coma, in particular, has the most potential for differentiating these groups based on aberrometry alone. Our findings are consistent with previous work by Maeda et al. (Ophthalmology. 2002 Nov;109(11):1996–2003). In this paper, they determined that spherical and coma–like aberrations were increased in keratoconus compared to normal. To our knowledge, our analysis is the first to compare aberrometry between normals and keratoconus, as well as keratoconus ‘suspects’. Our analysis also determines specifically the significance of vertical coma in kertoconus and keratoconus suspects.

 

 
Keywords: keratoconus • optical properties • clinical (human) or epidemiologic studies: risk factor assessment 
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