Purchase this article with an account.
M.W. Grinstaff, P.C. Kang, M.C. Wathier, M.A. Carnahan, T. Kim; Dendritic Adhesives to Secure Laser in situ Keratomileusis Flaps . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4995.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate a light activated and a self–gelling biodendrimer–based hydrogel adhesive for sealing laser in–situ keratomileusis (LASIK) flaps. Methods: LASIK flaps were created in 10 human eyebank eyes using the Hansatome microkeratome system. These eyes were then divided into two groups. Flaps in the first group (n=4) were secured with a laser–activated biodendrimer adhesive along the flap edge. In the second group (n=6), the flaps were secured with a self–gelling dendritic adhesive. Dry Merocel sponges were used to test the strength of flap adherence in both groups. The hinges of these flaps were cut with a scalpel blade and fluorescein dye was injected under the flap to observe any potential dye leakage along the flap edge. Results: The LASIK flaps were secured using both adhesives with no flap dislocation. There was no leakage of fluorescein dye observed indicating that an effective seal was made at the wound. Both adhesives were easy to apply, clear, and had a soft rubbery consistency. Conclusions: The biodendrimer–based adhesives are an effective alternative to sutures for securing LASIK flaps and as such may prove to be an effective treatment option for LASIK flap complications, such as epithelial ingrowth or flap dislocation. Support: This research was supported by the NIH. We also thank the North Carolina Eye Bank.
This PDF is available to Subscribers Only