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N. Cortes, R. Velasco, O. Baca, D. Viggiano, M. Calvillo; Outcome of Penetrating Keratoplasty With Corneas From Adult Donors . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5049.
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© ARVO (1962-2015); The Authors (2016-present)
PURPOSE: to describe the follow–up of patients receiving corneas from donors older than 70 years old and to determine whether there is a higher incidence of graft failure. METHODS: A retrospective and observational study was made. Patients who underwent penetrating keratoplasty receiving corneas from donors older than 70 years old, at the Fundación Hospital Nuestra Señora de la Luz in the last 5 years were studied. Donor cornea data (age, cell density, death to enucleation and preservation time and characteristics of the graft) were recorded from the Central Florida Lions Eye and Tissue Bank, Inc. Variables of receptor and transoperative procedures were taken from the charts. Preoperative indications and outcome of penetrating keratoplasty for every patient also were recorded. Pearson's coefficient was used to correlate these variables. Postoperative pachometry, and graft failure due to rejection were measured in a one year of follow–up. RESULTS: Seventy five consecutive patients were included. The mean age of donor was 73 ±2.5 years, 49 (65%) were male. The incidence of graft failure was 14.6%. Mean death to enucleation time was 7.48 hours, and for the preservation time was 7.12 days; although these times were larger in all the failures (10.48 hours and 8.5 days, respectively) we found no correlation (P > 0.05). The principal indications for keratoplasty were pseudophakic/aphakic bullous keratopathy, keratoconus, Fuch's dystrophy and regrafts. Sixty percent of the graft failures had a bullous keratopathy previously, in contrast, the keratoconus group achieved 100% of success. In this study we found no correlation between age of donor or cell density and whether higher incidence of gratf failure compared with patients receiving corneas from donors less than 60 years (16.3%) in our Institution. We found that 14.6% of corneal donors had an intraocular lens. Conclusions: Death to enucleation and preservation time, endothelial alterations and other factors were present in graft failure, but there was no correlation statistically. We found no relation between donor age and corneal transplant survival.
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