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D.S. Chu, D.J. Agriantonis, M.S. Roy; Electroretinogram Changes Associated With Vogt–Koyanagi–Harada Disease . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5124.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To describe electroretinogram (ERG) changes in patients with Vogt–Koyanagi–Harada disease (VKH) and to determine any potential correlation of these changes to the disease activity. Methods: We conducted a retrospective study of consecutive patients treated for VKH between February 2002 and November 2004. Full–field computerized ERG was recorded using standard procedures in 5 patients with VKH to evaluate cone and rod function. Patients were followed with complete ophthalmological examination. Results: The patients studied consisted of 3 females and 2 males with a mean age of 34.8 years. Three of the patients were Hispanic, 1 African–American, and 1 Asian. Four of the five patients showed varying degrees of active inflammation when ERG was performed. Three of the patients had abnormal optic discs and three patients had retinal pigment epithelial changes. Four of the five patients were actively being treated with systemic medications. The implicit time and amplitude of the dark–adapted rod b–wave were as follows. For right eyes the mean implicit time was 50.2 ms and the mean amplitude was 9.9 microvolts. For left eyes the mean implicit time was 50.3 ms and the mean amplitude was 10.6 microvolts. The implicit time and amplitude of the white light cone b–wave were as follows. For right eyes the mean implicit time was 27.6 ms and the mean amplitude was 17.7 microvolts. For left eyes the mean implicit time was 27.1 ms and the mean amplitude was 14.6 microvolts. No correlation is seen between cone or rod response and disease activity. Conclusions: ERG changes are observed in VKH patients. The changes in rod response are more prominent and more frequently observed than cone response changes. These changes do not appear to correlate with the disease activity.
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