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D. Watanabe, H. Takagi, K. Suzuma, M. Kurimoto, T. Ojima, T. Murakami, T. Kimura, A. Sakamoto, M. Kita, N. Yoshimura; Vitreous Levels of Erythropoietin and Vascular Endothelial Growth Factor in Patients With Retinal Vein Occlusion . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5189.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To investigate the levels of erythropoietin (Epo) and vascular endothelial growth factor (VEGF) in the vitreous of patients with retinal vein occlusion (RVO). Methods:The levels of Epo and VEGF were measured by radio–immunoassay and enzyme–linked immunosorbent assay in the vitreous of 62 eyes of 62 patients who underwent vitrectomy with RVO (32 eyes of 32 patients) and non–retinal vein occlusion ocular diseases (control) (30 eyes of 30 patients). Control eyes included 23 with idiopathic macular hole, 7 with retinal detachment with macular hole. The classification of RVO into ischemic and non–ischemic was made by fluorescein angiography. Results:RVO eyes included 12 with central retinal vein occlusion (CRVO) and 20 with branch retinal vein occlusion (BRVO). Vitreous level of Epo was significantly higher in patients with RVO (405.6 ± 412.3 mIU /ml) than in control (31.1 ± 14.2 mIU/ml)(P < 0.0001). For eyes with RVO, mean vitreous level of Epo was tend to be higher in the 23 eyes with ischemic RVO (494.3 ± 691.2 mIU /ml) than in the 9 eyes with non–ischemic RVO (179.1 ± 110.7 mIU /ml), however, the difference was not significant (P = 0.737). The vitreous concentration of VEGF was also significantly higher in patients with RVO (1005. 4 ± 950.3 pg/ml) than in control (3.27 ± 3.8 pg/ml)(P < 0.0001). Vitreous level of VEGF was significantly higher in ischemic RVO (1379.1 ± 2739.6 pg/ml) than in non–ischemic RVO (50.8 ± 85.6 pg/ml) (P = 0.034). The vitreous concentration of Epo was significantly correlated with that of VEGF in eyes with RVO (R = 0.475, P = 0.005). There was no significant relationship between plasma Epo level and vitreous Epo level. Conclusions:We found an increase and a correlation of both Epo and VEGF levels in the vitreous fluid of patients with RVO, which suggests both Epo and VEGF are related to retinal ischemia in RVO.
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