May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
The Dystrophic Clathrin–Dependent Endocytosis of Rod Bipolar Cells in the FVB/N Mouse Retina
S.–J. Park; E.–J. Lim; H.–J. Kim; K.–R. Choi; S.–J. Oh; M.–H. Chun
Author Affiliations & Notes
  • S.–J. Park
    Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • E.–J. Lim
    Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • H.–J. Kim
    Ophthalmology, College of Medicine, Ewa woman's University, Seoul, Republic of Korea
  • K.–R. Choi
    Ophthalmology, College of Medicine, Ewa woman's University, Seoul, Republic of Korea
  • S.–J. Oh
    Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • M.–H. Chun
    Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  S. Park, None; E. Lim, None; H. Kim, None; K. Choi, None; S. Oh, None; M. Chun, None.
  • Footnotes
    Support  Brain Korea 21Grant
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5257. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      The Dystrophic Clathrin–Dependent Endocytosis of Rod Bipolar Cells in the FVB/N Mouse Retina
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      S.–J. Park, E.–J. Lim, H.–J. Kim, K.–R. Choi, S.–J. Oh, M.–H. Chun; The Dystrophic Clathrin–Dependent Endocytosis of Rod Bipolar Cells in the FVB/N Mouse Retina . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5257.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Abstract: : Purpose: To investigate the changes of clathrin–dependent endocytosis at the axon terminal of rod bipolar cells in rd1 type model of retinitis pigmentosa, FVB/N mouse. Methods: The retinas of FVB/N mice at postnatal day (P) 12, 14, 16, 21 and 49 were immunostained with monoclonal antisera against clathrin (1:200,000, Chemicon) and dynamin (1:20,000, Chemicon) which are the markers of synaptic vesicle endocytosis. For double labeling, polyclonal antisera against PKCα (1:1,000, Santa Cruz), rod bipolar cell marker, was used. Results: From P12, photoreceptor cells started to degenerate, and at P21 the outer nuclear layer (ONL) consisted of 2–3 cell layers. In the control group, each clathrin and dynamin immunoreactivity expressed from P14 to P49 at the axon terminal of PKCα labeled rod bipolar cells. In the FVB/N group, each clathrin and dynamin immunoreactivity was not visible in all terminals of rod bipolar cells at P14 and disappeared by P21. Conclusions: In the FVB/N mouse retina, rod bipolar cells are devoid of clathrin–dependent endocytosis .

Keywords: retina • retinal degenerations: cell biology • bipolar cells 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×