May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Expression of Class a Macrophage Scavenger Receptor in Surgically Excised Choroidal Neovascular Membrane
Author Affiliations & Notes
  • E. Takahashi
    Ophthalmology and Visual Science,
    Kumamoto University Graduate School of Medical Sciences, Kumamoto City, Japan
  • Y. Inomata
    Ophthalmology and Visual Science,
    Kumamoto University Graduate School of Medical Sciences, Kumamoto City, Japan
  • A. Hirata
    Ophthalmology and Visual Science,
    Kumamoto University Graduate School of Medical Sciences, Kumamoto City, Japan
  • J. Hirahara
    Cell Pathology,
    Kumamoto University Graduate School of Medical Sciences, Kumamoto City, Japan
  • H. Sato
    Cell Pathology,
    Kumamoto University Graduate School of Medical Sciences, Kumamoto City, Japan
  • M. Takeya
    Cell Pathology,
    Kumamoto University Graduate School of Medical Sciences, Kumamoto City, Japan
  • H. Tanihara
    Ophthalmology and Visual Science,
    Kumamoto University Graduate School of Medical Sciences, Kumamoto City, Japan
  • Footnotes
    Commercial Relationships  E. Takahashi, None; Y. Inomata, None; A. Hirata, None; J. Hirahara, None; H. Sato, None; M. Takeya, None; H. Tanihara, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5298. doi:
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      E. Takahashi, Y. Inomata, A. Hirata, J. Hirahara, H. Sato, M. Takeya, H. Tanihara; Expression of Class a Macrophage Scavenger Receptor in Surgically Excised Choroidal Neovascular Membrane . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5298.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To examine expression of human class A macrophage scavenger receptor (SR–A) in surgically excised specimens of choroidal neovascular membrane (CNVM). Methods:Ten surgically excised CNVM specimens were obtained from patients with age–related macular degeneration in 6 patients, myopic choroidal neovascularization in 2 patients, and idiopathic choroidal neovascularization in 2 patients. These specimens were stained for SR–A, KP–1 to identify macrophages, and for von Willebrand (vWF) factor to detect vascular endothelial cells. The cell densities of SR–A in 200µm radius of retinal pigmented epithelial cells (RPE region) and outside of RPE region (non–RPE region) were calculated. One enucleated eye with massive supra–choroidal hemorrhage from CNVM was also examined. Results:KP–1 expression was detected in all examined CNVMs. SR–A positive cells were detected in a part of KP–1 positive cells (58 to 86%). The cell density of SR–A in RPE region was significantly higher than in non–RPE region (P<0.01). In the enucleated eye with CNV, a large number of SR–A and KP–1 positive cells were observed in choroidal tissue surrounding the CNV lesion. Some macrophages with KP–1 were also detected in normal choroidal tissue, however, no SR–A positive cells were found. Conclusions:SR–A, one of the major macrophage receptors related to the pathogenesis of atherosclerosis, was detected in CNV. It is suggested that macrophage differentiation and the resultant SR–A expression participates in the development of CNV.

Keywords: age-related macular degeneration • immunohistochemistry • choroid: neovascularization 
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