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E. Takahashi, Y. Inomata, A. Hirata, J. Hirahara, H. Sato, M. Takeya, H. Tanihara; Expression of Class a Macrophage Scavenger Receptor in Surgically Excised Choroidal Neovascular Membrane . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5298.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To examine expression of human class A macrophage scavenger receptor (SR–A) in surgically excised specimens of choroidal neovascular membrane (CNVM). Methods:Ten surgically excised CNVM specimens were obtained from patients with age–related macular degeneration in 6 patients, myopic choroidal neovascularization in 2 patients, and idiopathic choroidal neovascularization in 2 patients. These specimens were stained for SR–A, KP–1 to identify macrophages, and for von Willebrand (vWF) factor to detect vascular endothelial cells. The cell densities of SR–A in 200µm radius of retinal pigmented epithelial cells (RPE region) and outside of RPE region (non–RPE region) were calculated. One enucleated eye with massive supra–choroidal hemorrhage from CNVM was also examined. Results:KP–1 expression was detected in all examined CNVMs. SR–A positive cells were detected in a part of KP–1 positive cells (58 to 86%). The cell density of SR–A in RPE region was significantly higher than in non–RPE region (P<0.01). In the enucleated eye with CNV, a large number of SR–A and KP–1 positive cells were observed in choroidal tissue surrounding the CNV lesion. Some macrophages with KP–1 were also detected in normal choroidal tissue, however, no SR–A positive cells were found. Conclusions:SR–A, one of the major macrophage receptors related to the pathogenesis of atherosclerosis, was detected in CNV. It is suggested that macrophage differentiation and the resultant SR–A expression participates in the development of CNV.
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