May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Histopathologic Findings in Postmortem Eyes After Photodynamic Therapy (PDT)
Author Affiliations & Notes
  • S.J. Kang
    Ophthalmology, Emory Eye Center, Atlanta, GA
  • H.E. Benson
    Ophthalmology, Emory Eye Center, Atlanta, GA
  • P. Hnik
    QLT Inc., Vancouver, BC, Canada
  • P. Margaron
    QLT Inc., Vancouver, BC, Canada
  • H.E. Grossniklaus
    Ophthalmology, Emory Eye Center, Atlanta, GA
  • Footnotes
    Commercial Relationships  S.J. Kang, QLT Inc. F; H.E. Benson, QLT Inc. F; P. Hnik, QLT Inc. E; P. Margaron, QLT Inc. E; H.E. Grossniklaus, QLT Inc. F.
  • Footnotes
    Support  QLT Inc.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5304. doi:
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      S.J. Kang, H.E. Benson, P. Hnik, P. Margaron, H.E. Grossniklaus; Histopathologic Findings in Postmortem Eyes After Photodynamic Therapy (PDT) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5304.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To examine the histopathologic findings in eyes with choroidal neovascularization (CNV) after photodynamic therapy (PDT). Methods: Four eyes were obtained post–mortem from three patients with CNV from age–related macular degeneration (AMD) that had been treated with PDT. Serial sections through the posterior poles were obtained. Light microscopic examinations were made after staining with H&E, PAS, Masson trichrome or PTAH. Two–dimensional reconstructions were prepared. Results: The interval between PDT and death was 3 months in one patient and not obtained in the other two patients. Light microscopy showed a CNV enveloped with retinal pigment epithelium (RPE) in all eyes that had PDT. The CNV measured from 0.36 x 0.5 mm to 1.18 x 1.7 mm. Two eyes had type I (subRPE) growth pattern, one eye had combined (subRPE/subretinal) CNV, and one eye had both type I and combined CNV (total of five areas of CNV in four eyes). Fibrous tissue proliferation was present within CNV. The fibrous tissue contained few vascular channels in four of the five CNV membranes. All specimens contained at least some patent vascular channels within CNV and PTAH stain showed no evidence of thrombi formation within the vascular channels. The underlying choriocapillaries and choroidal vessels showed no abnormal findings. Conclusions: Although involution with fibrous tissue proliferation occurred in four of five (80%) of the CNVs, PDT did not result in permanent occlusion of the CNV membranes. If the CNV membranes were mature and not leaking this may be a possible mechanism of previously reported beneficial effects of PDT on photoreceptor and visual preservation. Underlying choroid did not show any light microscopic changes.

Keywords: photodynamic therapy • age-related macular degeneration • pathology: human 
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