May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Na–K–Cl Cotransporter 2 Immunoreactive Cells in the Guinea Pig Retina
E.–J. Lim; S.–J. Park; S.–J. Oh; M.–H. Chun
Author Affiliations & Notes
  • E.–J. Lim
    Anatomy, Catholic Univ Korea Coll Med, Seoul, Republic of Korea
  • S.–J. Park
    Anatomy, Catholic Univ Korea Coll Med, Seoul, Republic of Korea
  • S.–J. Oh
    Anatomy, Catholic Univ Korea Coll Med, Seoul, Republic of Korea
  • M.–H. Chun
    Anatomy, Catholic Univ Korea Coll Med, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  E. Lim, None; S. Park, None; S. Oh, None; M. Chun, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5352. doi:
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      E.–J. Lim, S.–J. Park, S.–J. Oh, M.–H. Chun; Na–K–Cl Cotransporter 2 Immunoreactive Cells in the Guinea Pig Retina . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5352.

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Abstract

Abstract: : Purpose: Na–K–Cl cotransporter 2 (NKCC2) is a class of ion transport proteins that transport Na, K, Cl ions into and out of cells in an electrically neuronal manner. This study was conducted to characterize NKCC2–labeled cells in the guinea pig retina using immunocytochemistry. Methods: Five retinas of adult guinea pig were used. Retinas were immunostained with polyclonal antisera against NKCC2 (1:1000, Chemicon) using indirect immunoflorescence. Results: NKCC2 immunoreactivity was present in horizontal cell bodies and their processes in the outer plexiform layer. Certain populations of bipolar cells were also labeled, and the axon terminals of these bipolar cells terminate in OFF sublamina of the inner plexiform layer. In addition, ganglion cells and displaced amacrine cells in the ganglion cell layer were also labeled. Conclusions: NKCC2 may transport Na, K, Cl ions in certain retinal neurons in the guinea pig retina.

Keywords: ion transporters • immunohistochemistry • retina 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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