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R. Nesher, O. Ezra – Nimni, E. Shumla, J. Gur, S. Hamisha; Squeezing Eye–drops From Their Container – A Model Testing Variation Among Bottles . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5373.
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The ease of eye–drop extraction from its container has never been studied, although it may play an important factor in compliance to treatment in elderly or disabled patients. A model was designed to compare the strength required to extract drops from bottles of different manufacturers.
The model included a fixed portion to which the bottle was attached and a mobile portion – a lever with two arms. Mounting weights on the long arm led to squeezing of the bottle by the short arm. Weight for each bottle was determined in a staircase manner. Endpoint determined as the minimal weight (in grams) required to extract a drop from its container within 3 seconds. Three sets of 41 different topical agents were tested in a masked fashion. Statistical analysis was performed by ANOVA.
Six different groups of topical agents were tested. The table depicts for each group the force range (in grams) required to squeeze a drop out of the bottle.
This model produces a value which integrates the factors that may contribute to the force required to squeeze an eye–drop from its container. The results show a large variation among bottles. This may need to be taken into consideration when prescribing eye–drops to older individuals or patients with arthritic hand problems.
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