May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Pharmacokinetic and Toxicity Studies of a New Intraocular Lens With Dexamethasone Drug Delivery System (IOL–DDS)
R.C. Siqueira; R. Jorge; S. Fialho; A. Cunha; L. Lucena; A. Maia; E. Ribeiro; BOPP
Author Affiliations & Notes
  • R.C. Siqueira
    Retina, Centro Especializado Ret E Vit, São Jose do Rio Preto, Brazil
  • R. Jorge
    Retina, USP, Ribeirão Preto, Brazil
  • S. Fialho
    Pharmacology, UFMG, Belo Horizonte, Brazil
  • A. Cunha
    Pharmacology, UFMG, Belo Horizonte, Brazil
  • L. Lucena
    Retina, Centro Especializado Ret E Vit, São Jose do Rio Preto, Brazil
  • A. Maia
    Veterinary, UNIRP, São Jose do Rio Preto, Brazil
  • E. Ribeiro
    Development, Visiontech, Belo Horizonte, Brazil
  • BOPP
    Retina, Centro Especializado Ret E Vit, São Jose do Rio Preto, Brazil
  • Footnotes
    Commercial Relationships  R.C. Siqueira, None; R. Jorge, None; S. Fialho, None; A. Cunha, None; L. Lucena, None; A. Maia, None; E. Ribeiro, None.
  • Footnotes
    Support  Fapesp
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5375. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Pharmacokinetic and Toxicity Studies of a New Intraocular Lens With Dexamethasone Drug Delivery System (IOL–DDS)
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      R.C. Siqueira, R. Jorge, S. Fialho, A. Cunha, L. Lucena, A. Maia, E. Ribeiro, BOPP; Pharmacokinetic and Toxicity Studies of a New Intraocular Lens With Dexamethasone Drug Delivery System (IOL–DDS) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5375.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Abstract: : Purpose: Evaluation of the short–term safety and pharmacokinetic behaviour of a new intraocular lens containing a dexamethasone drug delivery system (IOL–DDS) in rabbits’ eyes. Methods: : The study involved the implantation of a modified PMMA intraocular lens containing a biodegradable dexamethasone drug delivery system into the posterior chamber of the right eyes of nine New Zealand White rabbits. Slit lamp examinations were performed serially. The rabbits were killed and the globes were removed after 3, 6, and 9 days for corneal and retinal histology and determination of dexamethasone levels in the aqueous humor and vitreous Results: Adequate dexamethasone concentrations were detectable in the aqueous humor and vitreous throughout the nine days period. It was not observed any corneal or retinal histological changes in the implanted eyes Conclusions: The developed intraocular lens with dexamethasone drug delivery system is effective in the delivery of adequate levels of dexamethasone to aqueous humor and vitreous, without acute adverse effects on the cornea and retina. More studies are under development in order to determine the potential of this system in the treatment and prevention of cataract surgery inflammation.

Keywords: pharmacology • cataract • anterior segment 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept