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R.C. Siqueira, R. Jorge, S. Fialho, A. Cunha, L. Lucena, A. Maia, E. Ribeiro, BOPP; Pharmacokinetic and Toxicity Studies of a New Intraocular Lens With Dexamethasone Drug Delivery System (IOL–DDS) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5375.
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Purpose: Evaluation of the short–term safety and pharmacokinetic behaviour of a new intraocular lens containing a dexamethasone drug delivery system (IOL–DDS) in rabbits’ eyes. Methods: : The study involved the implantation of a modified PMMA intraocular lens containing a biodegradable dexamethasone drug delivery system into the posterior chamber of the right eyes of nine New Zealand White rabbits. Slit lamp examinations were performed serially. The rabbits were killed and the globes were removed after 3, 6, and 9 days for corneal and retinal histology and determination of dexamethasone levels in the aqueous humor and vitreous Results: Adequate dexamethasone concentrations were detectable in the aqueous humor and vitreous throughout the nine days period. It was not observed any corneal or retinal histological changes in the implanted eyes Conclusions: The developed intraocular lens with dexamethasone drug delivery system is effective in the delivery of adequate levels of dexamethasone to aqueous humor and vitreous, without acute adverse effects on the cornea and retina. More studies are under development in order to determine the potential of this system in the treatment and prevention of cataract surgery inflammation.
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