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H. Vosoghi, N. Patel, F. Gonzalez–Fernandez; Database to Study Epidemiology of Sebaceous Carcinoma . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5413.
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Purpose: Sebaceous carcinoma is a life–threatening malignancy that poses a significant challenge to both ophthalmologists and pathologists. Understanding why ocular Seb Ca is more prevalent in women and in the far east, and why Seb Ca is more common in the ocular adnexa compared with nonocular sites has been hampered by the lack of a database (Gonzalez–Fernandez et al. Ophthalmology 105:497–506,1998). To address these questions, we are establishing a database of published cases that would facilitate research into these issues. In the present study, we used this database to compare the number of reported cased in men and women during the past six years. Methods: We constructed a database in ACESS that includes all published cases of Seb Ca from 1966 to the present. Each case received a unique identifier. We probed the database from 1998–2004 focusing on gender differences and mortality. Exclusion criteria were: inadequate clinical information, a history of radiation, and cases associated with the Muir–Torre Syndrome, sebaceous nevus, and immunocompromised states. The remaining cases were evaluated for factors such as age, gender, and mortality. Results: During 1998–2004, 259 cases of Seb Ca were identified. Of the included cases, 187 involved ocular adnexa. 49 cases were not considered based on the exclusion criteria. Of the remaining 138 cases, 82 were female and 56 were male. The average age in females was 67 (SD =13.4 yrs, range 35–92) while that in males was 69.2 (SD = 11.5 yrs, range 47–96). 119 of the 138 cases reported on mortality with only 6 deaths due to Seb Ca (mortality = 5%). 113 cases reported survival at a mean follow–up of 48 months (range 2–204). Conclusions: Ocular sebaceous carcinoma has a female preponderance (female:male = 1.5:1.0), and was most common in the 7th and 8th decades. The majority of cases of Seb Ca affect the ocular adnexa. However, the extent of the incidence difference may be under–represented as extraocular Seb Ca tends to be more commonly reported. Our data imply an improved ability in early diagnosis. The Seb Ca database will be useful for epidemiological studies of this challenging neoplasm.
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