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T. Mizuguchi, Y. Otaka, A. Tanikawa, N. Horio, M. Horiguchi; Triamcinolone Acetonide Attenuates Anterior Chamber Inflammation After Combined Surgery of Vitrectomy and Phacoemulcification With Intraocular Lens Implantation for Idiopathtic Epiretinal Membrane . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5446.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To determine the effect of triamcinolone acetonide (TA) on anterior inflammation after combined surgery of vitrectomy and phacoemulcification with intraocular lens implantation (IOL surgery) in eyes with idiopathic epiretinal membrane (ERM). Methods: Thirty–one eyes of 29 patients with an idiopathic ERM underwent phacoemulcification, intraocular lens implantation, and vitrectomy, and use of TA was randomly determined during surgery. In 11 eyes of 10 patients (Group A), TA was not used during the surgery. In 10 eyes of 10 patients (Group B), 4 mg of TA was injected into the vitreous cavity immediately after the surgery. In 10 eyes of 9 patients (Group C), 20 mg of TA was injected under Tenon capsule during the surgery. Anterior chamber inflammation was measured using a laser flare cell meter at 1, 3, 5, 7, 14 day postoperatively. Results: The anterior chamber flare was significantly lower in Group B than in Group A at 3, 5, 7 day postoperatively with the maximum difference at 5 day (16.1 ± 4.7 vs. 11.4 ± 2.7, Group A vs. Group B, P < 0.01). The flare in Group C was significantly lower than that in Group A during the follow–up period. There was no difference in visual acuity in the 3 groups at 3 months after surgery. Conclusions: Our data suggests that both intravitreal injection and injection under Tenon capsule of TA attenuate anterior inflammation after vitrectomy with IOL surgery, and that the TA injection under Tenon capsule is more effective.
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