May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
A Novel Method to Oxygenate Intraocular Irrigation Fluids With an In–line Oxygenator
Author Affiliations & Notes
  • R.N. Khurana
    Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • Y.–H. Chang
    Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • A. Barnes
    Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • G. Fujii
    Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • E. de Juan, Jr
    Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • M. Humayun
    Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA
  • Footnotes
    Commercial Relationships  R.N. Khurana, None; Y. Chang, None; A. Barnes, None; G. Fujii, None; E. de Juan, Jr., Bausch & Lomb P; M. Humayun, Bausch & Lomb P.
  • Footnotes
    Support  Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5512. doi:
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    • Get Citation

      R.N. Khurana, Y.–H. Chang, A. Barnes, G. Fujii, E. de Juan, Jr, M. Humayun; A Novel Method to Oxygenate Intraocular Irrigation Fluids With an In–line Oxygenator . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5512.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Abstract:
 

Animal studies have demonstrated that oxygen delivered into the vitreous can prolong retinal function during times of ischemia. We describe a novel method to oxygenate intraocular irrigating fluids during vitreoretinal surgeries in–line. Solutions of either Lactated Ringers or Balanced Salt Solution (BSS) were oxygenated with the FE390 Stainless in–line Oxygenation Assembly (Beer, Beer, and More Beer, Concord, CA). After running a 100 ml of solution through the in–line oxygenator, oxygen saturation was measured with a dissolved oxygen meter (Figure 1). A control experiment involving the oxygenator without oxygen perfusion was performed. Paired t–tests were used to compare oxygen saturation changes before and after oxygenation. In comparison to the original solution of BSS, there was an increase in oxygen saturation of 162%±47 (n=40; p<0.05). Without oxygenation perfusion, there was only a 24% ±14 (n=40) increase in oxygen levels in the BSS solution which was significantly lower than the treated BSS solution (p<0.05). In comparison to the original solution of Lactated Ringers, there was an increase in oxygen saturation of 208%±21 (n=40; P<0.05). Without oxygenation perfusion, there was only a 21%±9 (n=40) gain in oxygen saturation in the control group of LR that was statistically lower as well (p<0.05). The in–line oxygenator is an efficient method to oxygenate BSS and LR fluids. It represents a potential efficient and convenient method to oxygenate irrigating solutions for vitreoretinal surgeries.

 

Figure 1:

 

 

 
Keywords: vitreoretinal surgery • retina • hypoxia 
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