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L. Wu, R. Velasquez, O. Montoya; Non–Infectious Endophthalmitis Associated With Trypan Blue Use in Cataract Surgery . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5547.
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Purpose: To report the clinical findings and management of three eyes that developed non–infectious endophthalmitis following routine trypan blue staining of the anterior lens capsule during uncomplicated phacoemulsification with a foldable lens implant. Methods: Retrospective case series. Results: On the first post–operative day, 17.6% (3/17) of eyes had an increased cellular response in the anterior chamber and anterior vitreous, 11.7% (2/17) had a hypopion and the fundus could not be visualized in 17.6% (3/17). Visual acuities at presentation ranged from 20/100 to 20/400. All eyes were initially managed with topical and oral steroids. Two eyes eventually underwent pars plana vitrectomy. Vitreous cultures were all negative. One eye had a repeat vitrectomy to remove an epiretinal membrane. Final visual acuity achieved was 20/80, 20/25 and 20/20. Conclusions: Trypan blue use may be associated with severe intraocular inflammation.
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