May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Effect of Intravitreal Injection of Autologous Plasmin Alone in Eyes With Diabetic Maculopathy
M. Tanaka; M. Kiyokawa; J. Inoue; A. Mizota; A. Murakami; A. Ichinose; M. Souri
Author Affiliations & Notes
  • M. Tanaka
    Department of Ophthalmology, Juntendo Univ Urayasu Hospital, Urayasu–shi, Japan
  • M. Kiyokawa
    Department of Ophthalmology, Juntendo Univ Urayasu Hospital, Urayasu–shi, Japan
  • J. Inoue
    Department of Ophthalmology, Juntendo Univ Urayasu Hospital, Urayasu–shi, Japan
  • A. Mizota
    Department of Ophthalmology, Juntendo Univ Urayasu Hospital, Urayasu–shi, Japan
  • A. Murakami
    Ophthalmology, Juntendo Univ School of Medicine, Tokyo, Japan
  • A. Ichinose
    Molecular Patho–Biochemistry and Patho–Biology, Yamagata University School of Medicine, Yamagata, Japan
  • M. Souri
    Molecular Patho–Biochemistry and Patho–Biology, Yamagata University School of Medicine, Yamagata, Japan
  • Footnotes
    Commercial Relationships  M. Tanaka, None; M. Kiyokawa, None; J. Inoue, None; A. Mizota, None; A. Murakami, None; A. Ichinose, None; M. Souri, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 5578. doi:
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      M. Tanaka, M. Kiyokawa, J. Inoue, A. Mizota, A. Murakami, A. Ichinose, M. Souri; Effect of Intravitreal Injection of Autologous Plasmin Alone in Eyes With Diabetic Maculopathy . Invest. Ophthalmol. Vis. Sci. 2005;46(13):5578.

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Abstract

Abstract: : Purpose:Plasmin is a protein kinase, and an intravitreal injection of plasmin can induce posterior vitreous detachment (PVD). The efficacy of autologous plasmin derived from patients own serum, as an adjunct to vitreous surgery has been reported for macular hole or diabetic retinopathy. The purpose of this study was to show the effect of intravitreal injection of autologous plasmin alone in eyes with diabetic maculopathy. Methods: Plasmin was derived from the patient’s own serum as previously reported. Eight eyes of 6 cases with diabetic maculopathy were injected with autologous plasmin. The dosage of plasmin ranged from 0.8 to 2.0 IUs. The visual acuity, visual field, OCT, B–mode ultrasonography, and ERGs were measured before and after the plasmin injection. Results: In all cases, a PVD developed within one day after the injection. A mild inflammation was observed in one patient injected with 2.0 IU of plasmin, but the inflammation was resolved within 3 days. In 4 eyes, the visual acuity recovered more than 2 lines. The OCT–determined retinal thickness was reduced, and the ERGs were not changed in all cases. Conclusions: Autologous plasmin injection alone might be useful to treat diabetic maculopathy.

Keywords: diabetic retinopathy • vitreous • vitreoretinal surgery 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2023 Association for Research in Vision and Ophthalmology.
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