Abstract
Abstract: :
Purpose:Cytokines and others growth factors such as interleukins play an important role in the pathogenesis of proliferative vitreoretinopathy (PVR). Interindividual variations in the capacity of cytokine production has been shown to correlate with polymorphism in cytokine genes. The purpose of this study was to analyze the possible role of these cytokine gene variations in the development of PVR.Methods: Single nucleotide mutations were analyzed in five cytokines (tumour necrosis factor–α (TNF–α), transforming growth factor ß1 (TGF–ß1), interferon γ (IFN–γ), interleukin 6 (IL–6) and interleukin 10 (IL–10)) in two groups of patients diagnosed of retinal detachment (RD): group RD (27 patients without PVR), and group PVR (31 patients with PVR) and a control group. All individuals were classified as high or low producers of TNF–α and IL–6 and high, intermediate and low producers of TGF–ß1, IFN–γ, and IL–10. Results: An increased frequency of high producer phenotypes of TGF–ß1 was found in PVR patients when compared with controls and RD. The genotype distribution of the codon 10 polymorphism was different between PVR and RD patients (p=0,018) and between PVR and controls in codon 25 (p=0,011). There was a higher incidence of allele T in codon 10 in PVR patients when compared with RD group. No statistically significant differences were observed between groups of patients and control group in the rest of polymorphisms. Conclusions:An association between TGF–ß1 gene polymorphism and the development of PVR was detected in this study. Further studies are necessary to confirm this finding and to establish its clinical relevance
Keywords: retinal detachment • proliferative vitreoretinopathy • genetics