Abstract
Abstract: :
Purpose: To use a high–speed corneal and anterior segment optical coherence tomography (CAS–OCT) system to image corneal pathologies. Methods: A high–speed CAS–OCT system was developed. It uses a longer wavelength (1.3 microns) compared to retina OCT systems (0.8 microns) and performs 2000 axial scans/second. OCT scans were performed in 3 patients, one each with spheroidal degeneration, granular dystrophy, and keratoconus with hydrops. Results: Full–thickness imaging of the cornea in all cases was possible. In the keratoconus case with hydrops it was possible to visualize corneal thinning and a Descemet’s membrane tear with detachment. In the spheroidal degeneration case the opacities were found within the epithelium or had a sub–epithelial location. In the granular dystrophy case the greatest concentration of lesions was localized to the anterior stroma with fewer in the deeper layers. Conclusions: The CAS–OCT prototype allowed non–contact visualization of corneal pathologies.
Keywords: cornea: clinical science • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical