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F.A. G. J. Eggink, J.J. M. Willemse Assink, G. van Rij; Excimer laser treatment of topographic central islands in combination with mitomycine–C results in a hyperopic shift . Invest. Ophthalmol. Vis. Sci. 2004;45(13):158.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate the efficacy of using central reablation in combination with prophylactic application of 0.02% mitomycine–C, for the treatment of topographic central islands in combination with haze, following photorefractive keratectomy (PRK). Methods: Seven patient eyes with mean preoperative refractive spherical equivalent of –5.0 D, developed central islands in combination with haze which persisted more than 4 months. All patients lost more than 2 lines of BSCVA (mean 5 lines) and complained of visual disturbance. Reablation was tailored to each eye using the Technolas 217 excimer laser, based on the diameter and power of the topographic central island using the Munnerlyn formula. After ablation, the stromal surface was treated with a 0.02% mitomycine–C solution during 20 to 30 seconds using a soaked merocel sponge. The follow up of all patients was at least 6 months after the treatment with mitomycine–C. Results: Six months after the procedure, the visual loss was reduced to one line of the preoperative BSCVA level in six eyes (85%). One eye lost 3 lines of preoperative BSCVA. Mean postoperative refractive equivalent was + 1.3 D. Conclusions: Repeated laser ablation combined with the application of topical mitomycine–C to remove central islands and haze is effective. However it results in a hyperopic shift of + 1.3 D.
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