May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Time Temperature Dependence of Corneal Thermal Shrinkage
Author Affiliations & Notes
  • D. Borja
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL
  • F. Manns
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL
  • W. Lee
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL
  • P. Lamar
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL
    Dept of Ophthalmology, Rudolf Foundation Hospital and Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria
  • J.–M. Parel
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL
  • Footnotes
    Commercial Relationships  D. Borja, None; F. Manns, None; W. Lee, None; P. Lamar, None; J. Parel, None.
  • Footnotes
    Support  Whitaker Foundation; Florida Lions Eye Bank; Research to Prevent Blindness, New York, NY; Henri
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 182. doi:
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    • Get Citation

      D. Borja, F. Manns, W. Lee, P. Lamar, J.–M. Parel; Time Temperature Dependence of Corneal Thermal Shrinkage . Invest. Ophthalmol. Vis. Sci. 2004;45(13):182.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To determine the effects of temperature and heating duration on the kinetics of thermal shrinkage in corneal strips. Methods: Thermal shrinkage was induced and measured in 2x4mm corneal strips immersed in 25% Dextran solution under a constant load. A study was performed on 57 Florida Lions Eye Bank eyes to determine the effect of temperature on the amount and rate of thermal shrinkage. The temperature of corneal strips was increased from 33ºC to 60, 65, 70, 75, 80 and 90º for 5 minutes and returned to 33ºC. Further experiments were performed on 20 human cadaver eyes to determine the effects of heating duration on shrinkage. The temperature of corneal strips was raised from 33ºC to 65ºC for 5, 10, 30 and 45 minutes. Statistical analysis was performed to determine the effects of temperature, heating duration, and age on the amount and kinetics of shrinkage. Results: At temperatures below 75ºC there was significant shrinkage regression after heating. There was no statistically significant regression at temperatures above 75ºC. The shrinkage time constants where calculated to be 67, 84, 121, 560 and 1112s at 80, 75, 70, 65, and 60ºC respectively. Increasing the time of heating produced an exponential decrease in shrinkage regression at 65ºC, with a time constant of 945s. Conclusions: Corneal thermal shrinkage is a slow process requiring temperatures above 75ºC for durations longer than 45s in order to minimize shrinkage regression at the end of heating. Thermal keratoplasty procedures should therefore aim at producing temperatures above 75ºC to produce efficient permanent shrinkage. Support: Whitaker Foundation; Florida Lions Eye Bank; Research to Prevent Blindness, New York, NY; Henri

Keywords: refractive surgery: other technologies 
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