May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Changes in Visual Function in Children with Infantile Spasms on Vigabatrin Therapy.
S. Bega; S.E. Morong; T. Wright; R. Nobile; J.R. Buncic; C.A. Westall
Author Affiliations & Notes
  • S. Bega
    Department of Ophthalmology, Hospital for Sick Children, Toronto, ON, Canada
    Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
  • S.E. Morong
    Department of Ophthalmology, Hospital for Sick Children, Toronto, ON, Canada
    Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
  • T. Wright
    Department of Ophthalmology, Hospital for Sick Children, Toronto, ON, Canada
  • R. Nobile
    Department of Ophthalmology, Hospital for Sick Children, Toronto, ON, Canada
  • J.R. Buncic
    Department of Ophthalmology, Hospital for Sick Children, Toronto, ON, Canada
  • C.A. Westall
    Department of Ophthalmology, Hospital for Sick Children, Toronto, ON, Canada
    Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
  • Footnotes
    Commercial Relationships  S. Bega, None; S.E. Morong, None; T. Wright, None; R. Nobile, None; J.R. Buncic, None; C.A. Westall, None.
  • Footnotes
    Support  CIHR grant #51712, Aventis Pharma
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 253. doi:
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      S. Bega, S.E. Morong, T. Wright, R. Nobile, J.R. Buncic, C.A. Westall; Changes in Visual Function in Children with Infantile Spasms on Vigabatrin Therapy. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):253.

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Abstract

Abstract: : Purpose:The amplitude of the 30 Hz electroretinogram (ERG) has been associated with vigabatrin toxicity. The purpose is to determine if contrast sensitivity determined by visual evoked potential (VEP) changes with change in 30 Hz flicker response and whether the VEP contrast sensitivity is affected in cases of vigabatrin toxicity. Methods:Sweep VEPs were used to assess contrast sensitivity (CS) and visual acuity in 9 children with infantile spasms before and during vigabatrin treatment. Electroretinograms were recorded according to ISCEV standards in the same children. The children (aged 5 months – 20 months, mean 10 months) were tested longitudinally at 0, 5 and 10 months following start of vigabatrin therapy. Results:Contrast sensitivity values and the log of the ERG 30 Hz flicker amplitude were obtained. For data analysis, we subtracted values from the final visit from values for the first visit (prior to initiation of vigabatrin therapy). The subtraction provided values for (delta ERG and delta CS). Eight children showed reduction in CS over time; 4 showed reduction in ERG flicker amplitude. A positive correlation of 0.53 was found between delta 30 Hz ERG and delta CS, indicating that change in the ERG 30 Hz flicker response is associated with change in CS. Importantly two children showed ophthalmoscopic evidence of toxicity on the final visit. Both children showed reduction in CS at the final visit. Interestingly CS was often lower than age match controls before and during vigabatrin treatment. Conclusions:Contrast sensitivity may prove to be an indicator of vigabatrin attributed toxicity in children with infantile spasms. The current study had no control group of children with infantile spasms taking other anti–epileptic drug treatment. It is important to distinguish between two possible contributors to ERG and CS changes: vigabatrin treatment or infantile spasms attributed developmental delays. Future studies will be compare CS from children with infantile spasms taking vigabatrin to a group of children with infantile spasms taking other anti–epileptic drugs.

Keywords: drug toxicity/drug effects • electroretinography: clinical • electrophysiology: clinical 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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