May 2004
Volume 45, Issue 13
ARVO Annual Meeting Abstract  |   May 2004
Electrophysiologic and visual field disturbances evolution in patients treated with vigabatrin
Author Affiliations & Notes
  • F.N. Bourcier
    Ophthalmology, Robert Ballanger Hospital, France, France
  • B. De Toffol
    Tours CHU, France, France
  • S. Majzoub
    Tours CHU, France, France
  • M. Delplace
    Tours CHU, France, France
  • Footnotes
    Commercial Relationships  F.N. Bourcier, None; B. De Toffol, None; S. Majzoub, None; M. Delplace, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 255. doi:
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      F.N. Bourcier, B. De Toffol, S. Majzoub, M. Delplace; Electrophysiologic and visual field disturbances evolution in patients treated with vigabatrin . Invest. Ophthalmol. Vis. Sci. 2004;45(13):255.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: To report visual field and electrophysiologic disturbances evolution in patients who were treated with vigabatrin (VGB). Methods: Prospective case series.12 patients with a mean follow–up of 3 years after cessation vigabatrin therapy were included. Complete Ophthalmologic evaluation, visual field (static and kinetic), electro–oculogram (EOG), electroretinogram (ERG) and visual evoked potential (VEP) were analysed. Results: Reduced Arden ratio and flickers amplitude precede peripheral visual field constriction in 10 cases. Visual acuity, fundus, desaturated color vision and VEP were normal in all cases. One to 5 years follow–up after VGB withdrawal, Arden ratios return to normal whereas there was persistent peripheral visual field constriction and reduced flickers amplitude in all cases. No ophthalmologic adverse effects were observed with new antiepileptic drugs. Conclusion: persistent EOG and flickers anomalies are of predictive value for visual field impairments. Peripheral visual field constrictions persist as a sequel of VGB retinal toxicity.

Keywords: electrophysiology: clinical • visual fields • retina 

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