May 2004
Volume 45, Issue 13
ARVO Annual Meeting Abstract  |   May 2004
Latanoprost in the treatment of essential blepharospasm
Author Affiliations & Notes
  • K.J. Bhan
    Ophthalmology Department, Leeds General Infirmary, Leeds, United Kingdom
  • O. Backhouse
    Ophthalmology Department, Leeds General Infirmary, Leeds, United Kingdom
  • Footnotes
    Commercial Relationships  K.J. Bhan, None; O. Backhouse, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 259. doi:
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      K.J. Bhan, O. Backhouse; Latanoprost in the treatment of essential blepharospasm . Invest. Ophthalmol. Vis. Sci. 2004;45(13):259.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: To assess claims that latanoprost is useful in the treatment of essential blepharospasm Methods: In a prospective double–blind study, patients with essential blepharospasm, previously treated with botulinum toxin injections, were randomised to receive either once–daily latanoptost or placebo. Patients were asked to grade the severity of their symptoms using a standard grading scale before and during treatment (at 0, 6 and 12 weeks. Results: 40 patients were approached and of these, 8 patients were happy to enroll. Following randomisation, 4 received latanoprost and 4 received placebo. 4 patients expressed no change in their symptoms (2 latanoprost and 2 placebo). 5 patients withdrew from the study at the 6–week assessment. At 12 weeks, 3 patients remaoned, all of whom were from the latanoprost group (2 of these expressed no difference; 1 expressed deterioration). Statistical analysis confirmed no significant difference in the outcome between the 2 groups. Conclusions: This study has failed to support the suggestion that latanoprost is any more effective than placebo in the management of essential blepharospasm

Keywords: clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • eyelid • visual impairment: neuro–ophthalmological disease 

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