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M.T. Hamilton, D.E. E. Holck, S. Marshall, J.A. Foster, K.E. Morgenstern, S.M. Blaydon, S. Demartelaere; Comparison of High–Dose Botulinum Toxin Type B to Botulinum Toxin Type A in the Amelioration of Lateral Canthal Wrinkles . Invest. Ophthalmol. Vis. Sci. 2004;45(13):29.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare botulinum toxin Type A to Type B in the treatment of lateral canthal rhytids. Methods: In a double–masked fashion, 20 pateints received injections of 15 units botulinum A on one lateral canthal area and 2,250 units of botulinum B on the contralateral side. Daily photos were obtained to Day 8, and weekly photos thereafter. The photos were graded by masked reviewers for static and dynamic wrinkles. Results: Botulinum toxin B showed much earlier onset of action with a shorter duration of action than botulinum toxin A. Side effects were significantly greater with toxin Type B. Conclusions: Even at higher doses, botulinum toxin Type B offers more rapid onset but significantly shorter duration than Type A. Type B also appears to diffuse more than Type A.
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