May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Intraocular lens with bactericidal activity by photocatalytic coating
M.–L. Tsai; C.–J. Chang; D.–W. Lu; Y.–P. Tsao; C.–T. Chen; C.–L. Hung
Author Affiliations & Notes
  • M.–L. Tsai
    Ophthalmology, Tr–Service Gen Hosp, Taipei, Taiwan Republic of China
  • C.–J. Chang
    Ophthalmology, Tr–Service Gen Hosp, Taipei, Taiwan Republic of China
  • D.–W. Lu
    Ophthalmology, Tr–Service Gen Hosp, Taipei, Taiwan Republic of China
  • Y.–P. Tsao
    Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan Republic of China
  • C.–T. Chen
    Ophthalmology, Tr–Service Gen Hosp, Taipei, Taiwan Republic of China
  • C.–L. Hung
    Ophthalmology, Tainan municipal hopital, Tainan, Taiwan Republic of China
    Ophthalmology, National Cheng Kung University, Tainan, Taiwan Republic of China
  • Footnotes
    Commercial Relationships  M. Tsai, None; C. Chang, None; D. Lu, None; Y. Tsao, None; C. Chen, None; C. Hung, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 317. doi:
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      M.–L. Tsai, C.–J. Chang, D.–W. Lu, Y.–P. Tsao, C.–T. Chen, C.–L. Hung; Intraocular lens with bactericidal activity by photocatalytic coating . Invest. Ophthalmol. Vis. Sci. 2004;45(13):317.

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Abstract

Abstract: : Purpose:To evaluate the effect of intraocular lens (IOL) with photocatalytic coating on bacteria. Methods:The titanium dioxides with photocatalytic activity was coated onto the surface of lens body of IOL by electronic beam–assisted physical vapor deposition. Thereafter, the coating was evaluated by scanning electronic microscope (SEM). The component of coating was analyzed by auger electron spectroscopy (AES). The photocatalytic activity was investigated by X–ray diffraction (XRD). To evaluate the effect of the coating on bacteria, the IOL with or without photocatalytic coating was placed in the bottom of different culture wells groups. The bacteria suspension (E.coli; 1x105) was then added into each culture well for pre–treatment with UV or without UV exposure. After 1 hour pre–treatment, the suspension was collected for lipid peroxidation test (MDA–TBA assay) and bacterial colony–forming assay to evaluate the effect of IOL with photocatalytic coating on bacteria. Results:The crossing section of SEM showed that tinanium dioxides would be coated onto the surface of IOL by electronic beam–assisted physical vapor deposition. AES revealed the component of the coating is titanium dioxide. The analysis of XRD revealed the coating possessed photocatalyic activity. MDA–TBA assay showed that bacteria would be oxidized by the coating under UV irridation. Bacterial colony–forming further confirm that bacteria would be destroyed by the coating. Conclusions:Titanium dioxides with photocatalytic activity can be coated onto the surface of lens body of IOL by electronic beam–assisted physical vapor deposition. The IOL with photocatalytic coating can oxidize bacteria and inhibit intraocular infection. Application of material with photocatalytic activity is potential in the prevention and treatment of ocular diseases.

Keywords: cataract • endophthalmitis • oxidation/oxidative or free radical damage 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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