May 2004
Volume 45, Issue 13
ARVO Annual Meeting Abstract  |   May 2004
A method for the safe administration of toxic agents to prevent posterior capsule opacification (PCO)
Author Affiliations & Notes
  • P.G. Soderberg
    St. Erik's Eye Hospital, Karolinska Inst, Stockholm, Sweden
  • S. Lofgren
    St. Erik's Eye Hospital, Karolinska Inst, Stockholm, Sweden
  • J.C. Merriam
    Columbia University, Edward S. Harkness Eye Institute, New York, NY
  • J.B. Holmén
    Phaco Treat AB, Uppsala, Sweden
  • Footnotes
    Commercial Relationships  P.G. Soderberg, None; S. Lofgren, None; J.C. Merriam, None; J.B. Holmén, Phaco Treat AB I, E, P.
  • Footnotes
    Support  KI research funds
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 367. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P.G. Soderberg, S. Lofgren, J.C. Merriam, J.B. Holmén; A method for the safe administration of toxic agents to prevent posterior capsule opacification (PCO) . Invest. Ophthalmol. Vis. Sci. 2004;45(13):367.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Abstract: : Purpose: PCO is one of the most frequent complications of cataract surgery and is a major obstacle to the use of accommodative lenses. Lens epithelial cells can be destroyed chemically, but it is important to administer epitheliotoxic drugs safely to the capsular bag. This pilot study demonstrates a patented method to apply the detergent saponine to the capsule during cataract surgery to prevent PCO. Methods: Phacoemulsification was performed in rabbits using a peripheral mini–capsulorhexis. The capsule was expanded with air, which was limited to the capsule by filling the anterior chamber with viscoelastic. A control solution of trypan blue or a test solution of trypan blue with the detergent saponine was injected into the gas–expanded lens capsule. With trypan blue the surgeon could visualize leakage from the capsule. After 60 seconds, the control or test solutions were removed by irrigation and aspiration. Two weeks after surgery pachymetry was performed, and the rabbits were sacrificed. The anterior segments were evaluated with light microscopy. Results: In the saponine treated eyes lens epithelial cells demonstrated vacuolization and moderate damage. In control eyes the lens epithelial cells appeared normal. There was no difference in corneal thickness or morphology between control and treated eyes. Conclusions: Saponine is epitheliotoxic and may be administrated safely with the patented method, demonstrating its potential as a treatment to prevent PCO.

Keywords: posterior capsular opacification (PCO) • pharmacology • drug toxicity/drug effects 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.