May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Suppression of experimental choroidal neovascularization by subretinal injection of triamcinolone acetonide
C.–C. Lai; W.–C. Wu; M.–H. Sun; L.–H. Chuang; K. Lin
Author Affiliations & Notes
  • C.–C. Lai
    Ophthalmology, Chang Gung Memorial Hospital, Kwei–Shan, Taiwan Republic of China
  • W.–C. Wu
    Ophthalmology, Chang Gung Memorial Hospital, Kwei–Shan, Taiwan Republic of China
  • M.–H. Sun
    Ophthalmology, Chang Gung Memorial Hospital, Kwei–Shan, Taiwan Republic of China
  • L.–H. Chuang
    Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan Republic of China
  • K. Lin
    Ophthalmology, Chang Gung Memorial Hospital, Kwei–Shan, Taiwan Republic of China
  • Footnotes
    Commercial Relationships  C. Lai, None; W. Wu, None; M. Sun, None; L. Chuang, None; K. Lin, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 471. doi:
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      C.–C. Lai, W.–C. Wu, M.–H. Sun, L.–H. Chuang, K. Lin; Suppression of experimental choroidal neovascularization by subretinal injection of triamcinolone acetonide . Invest. Ophthalmol. Vis. Sci. 2004;45(13):471.

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Abstract

Abstract: : Purpose: To determine the efficacy and safety of subretinal injection of triamcinolone acetonide (TA) in suppression of experimental choroidal neovascularization (CNV) in a pigmented rat model. Methods: Choroidal neovascularization (CNV) was generated by krypton laser photocoagulation on Brown Norway rats. Triamcinolone acetonide (TA) and balanced salt solution (BSS) were injected subretinally immediately after laser injury. The number and sizes of CNV were evaluated by retinal flatmount after intravenous perfusion with fluorescein isothiocyanate–dextran (FITC–dextran) and examined under fluorescence microscope. Electroretinograms (ERGs) were recorded to study any possibility of retinal toxicity of TA after the injections. Results: FITC–dextran angiogram revealed significant reduction of the average sizes and total area of CNV lesion in TA injected eyes when compared with BSS injected eyes. However, ERG study showed retinal toxicity in high concentration of TA injection. Conclusion: Subretinal injection of TA can significantly reduce the number and sizes of experimental CNV lesion. TA caused retinal toxicity in high concentration.

Keywords: choroid: neovascularization • retina • age–related macular degeneration 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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