Topical Brinzolamide for the Treatment of Idiopathic Central Serous Chorioretinopathy

Abstract

Abstract: : Purpose: To determine the eficacy and safety of topical brinzolamide in the treatment of Idiopathic Central Serous Chorioretinopathy (ICSC). Patients and methods: A prospective, longitudinal, double–blind, comparative study was designed which included patients with recent diagnosis of ICSC from june 2002 to october 2003. They were randomly divided into: Group I which recevied treatment with topical brinzolamide 2% bid; and Group II, which recevied polivinilic alcohol (placebo) bid. All patients were follow up tree months minimal after of recovery. We studied sintomatic and clinical recovery time, complications, fluorangiografic hot spots and visual acuity. Results:We included 16 patients, 3 were excluded and 7 were included in group I and 6 in group II. We found statistical significancy (p 0.03) in time of recovery clinic and a tendency toward sintomatic recovery (p 0.07). Complications were seen more often in group II (p 0.03) with a statistical significancy. No adverse effects were seen with the use of brinzolamide and there was good tolerance. Conclusions:Brinzolamide may shorten the time of recovery of ICSC, prevent complications and is safe to use.

Keywords: enzymes/enzyme inhibitors • retina • retinal adhesion