May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
ABO antigen blood–group compatibility in corneal graft rejection
Author Affiliations & Notes
  • T. Soma
    Dept Ophthalmology, Osaka Univ Med Sch, Suita, Japan
  • K. Nishida
    Dept Ophthalmology, Osaka Univ Med Sch, Suita, Japan
  • S. Sakimoto
    Dept Ophthalmology, Osaka Univ Med Sch, Suita, Japan
  • N. Maeda
    Dept Ophthalmology, Osaka Univ Med Sch, Suita, Japan
  • H. Watanabe
    Dept Ophthalmology, Osaka Univ Med Sch, Suita, Japan
  • Y. Tano
    Dept Ophthalmology, Osaka Univ Med Sch, Suita, Japan
  • Footnotes
    Commercial Relationships  T. Soma, None; K. Nishida, None; S. Sakimoto, None; N. Maeda, None; H. Watanabe, None; Y. Tano, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 607. doi:
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    • Get Citation

      T. Soma, K. Nishida, S. Sakimoto, N. Maeda, H. Watanabe, Y. Tano; ABO antigen blood–group compatibility in corneal graft rejection . Invest. Ophthalmol. Vis. Sci. 2004;45(13):607.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To determine whether the ABO antigen blood–group compatibility and other preoperative factors affected corneal graft rejection. Methods: Ninety–seven patients with 104 penetrating keratoplasties performed between 1997 and 2003 were retrospectively analyzed. Risk factors for corneal graft rejection were examined using the Cox proportional regression model. The 104 grafts were divided into a high–risk group and a low–risk group based on the above analysis. The effect of ABO compatibility on graft rejection was analyzed by the Kaplan–Meier method and compared with the log–rank test for each group. Results:The corneal graft was rejected in 15 eyes (14.3%). Three factors were found to increase the risk of graft rejection significantly; two or more quadrants of corneal vascularization (relative risk=7.36, P=0.003), anterior synechia (relative risk=7.15, P=0.003), and the number of previous grafts (relative risk=1.86, P=0.009). ABO compatibility did not significantly affect graft rejection (relative risk = 0.44, P=0.14). In addition, ABO incompatibility was not a significant risk factor for graft rejection in both the high– risk group (P =0.15) or in the low–risk group (P =0.57). Conclusions: The association between ABO antigen blood–group compatibility and corneal graft rejection was not significant.

Keywords: transplantation • cornea: clinical science 
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