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L.A. Herrygers, R. Noecker, L. Kearsley, N. Kim; Evaluation of the Effect of Various Artificial Tears on Latanoprost–Induced Corneal Toxicity in Rabbits . Invest. Ophthalmol. Vis. Sci. 2004;45(13):76.
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Purpose: To evaluate the effect of various artificial tear solutions on the corneal epithelium used in combination chronically with latanoprost. Methods: Eighteen eyes of nine New Zealand Rabbits were dosed with one drop of latanoprost daily for one month. Eight eyes were also randomized to receive a BAK containing artificial tear BID or polyquad containing artificial tear BID. Eight additional eyes were used as controls and received no drops. After one month of treatment with this regimen, the animals were sacrificed and the corneas were processed and evaluated with scanning electron microscopy (SEM). Two masked observers graded the corneal epithelial damage according to a standard scale. The scale rates damage from 1 (minimal damage) to 5 (complete loss of epithelium). Results: The mean damage score for the control eyes was 1.0, the mean damage score for corneas receiving latanoprost alone was 1.5, those receiving latanoprost and the polyquad artificial tear 1.6, and latanoprost and BAK artificial tear 2.8. All of the corneas receiving drops had more damage than controls (p<0.01). There was no difference between corneas receiving Xalatan alone and those receiving latanoprost and polyquad tears (p= 0.5). Those corneas receiving both latanoprost and BAK tears had more damage than any of the other groups (p<0.01). Conclusions: The addition of a treatment regimen with artificial tears containing BAK to corneas receiving Latanoprost results in a significant amount of corneal damage. The effect on an artificial tear containing the preservative polyquad is neutral on latanoprost–related corneal damage.
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