May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Ultra–high speed and ultra–high resolution optical coherence tomography and optical Doppler tomography
Author Affiliations & Notes
  • J.F. de Boer
    Dermatology, Wellman Center– MGH – BAR 724, Boston, MA
  • B. Cense
    Dermatology, Wellman Center– MGH – BAR 724, Boston, MA
  • N. Nassif
    Dermatology, Wellman Center– MGH – BAR 724, Boston, MA
  • B.R. White
    Dermatology, Wellman Center– MGH – BAR 724, Boston, MA
  • B.H. Park
    Dermatology, Wellman Center– MGH – BAR 724, Boston, MA
  • M.C. Pierce
    Dermatology, Wellman Center– MGH – BAR 724, Boston, MA
  • G.J. Tearney
    Dermatology, Wellman Center– MGH – BAR 724, Boston, MA
  • B.E. Bouma
    Dermatology, Wellman Center– MGH – BAR 724, Boston, MA
  • T.C. Chen
    Ophthalmology, Massachussetts Eye and Ear Infirmary, Boston, MA
  • Footnotes
    Commercial Relationships  J.F. de Boer, MGH P; B. Cense, None; N. Nassif, None; B.R. White, None; B.H. Park, None; M.C. Pierce, None; G.J. Tearney, MGH P; B.E. Bouma, MGH P; T.C. Chen, None.
  • Footnotes
    Support  1R24 EY12877
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1139. doi:
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      J.F. de Boer, B. Cense, N. Nassif, B.R. White, B.H. Park, M.C. Pierce, G.J. Tearney, B.E. Bouma, T.C. Chen; Ultra–high speed and ultra–high resolution optical coherence tomography and optical Doppler tomography . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1139.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Optical Coherence Tomography is a non–invasivemethod of creating cross sectional images of the retina. Howevercurrent OCT clinical instruments are limited by acquisitionspeed (1.28 seconds per image) preventing comprehensive screeningof large retinal area’s. We present a new technology thatis 75 times faster and has a 2 fold better axial resolutionthan current clinical instruments at the same retinal lightexposure (600 µW) without compromising signal to noise.Methods: A clinical OCT instrument was developed based on SpectralDomain OCTResults: OCT images were acquired at video rate (29 frames persecond, 1000 depth profiles per frame) with better than 5 µmaxial resolution. Artifacts due to subject motion were significantlyreduced, allowing mapping of structural tomography and trueretinal topography. Doppler OCT allowed determination of pulsatileretinal flow in arteries and veins, quantitative determinationof the cardiac cycle, and flow determination in retinal capillaries.Conclusions: Ultra high speed SD–OCT allows for comprehensivescreening of large area’s and 3–D volume renderingof optic nerve head and fovea of data acquired within 10 seconds.This advance in OCT technology will have significant impact,since accurate knowledge of retinal structure and blood flowdynamics is important in not only the treatment but also understandingthe pathophysiology of many diseases, including glaucoma. 

  Figures: In vivo SD–OCT structural and Doppler imagesof the human retina around the optic nerve head acquired in1/29 sec.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • nerve fiber layer • macula/fovea 
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