May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Detection of Angiostatin and Endostatin in Human Uveal Melanoma
U.C. Schaller; A.H. Wolf; U.C. Welge Luessen; A.J. Mueller; A. Kampik
Author Affiliations & Notes
  • U.C. Schaller
    Dept Ophthalmology, Ludwig–Maximilians Universitat, Munich, Germany
  • A.H. Wolf
    Dept Ophthalmology, Ludwig–Maximilians Universitat, Munich, Germany
  • U.C. Welge Luessen
    Dept Ophthalmology, Ludwig–Maximilians Universitat, Munich, Germany
  • A.J. Mueller
    Dept Ophthalmology, Ludwig–Maximilians Universitat, Munich, Germany
  • A. Kampik
    Dept Ophthalmology, Ludwig–Maximilians Universitat, Munich, Germany
  • Footnotes
    Commercial Relationships  U.C. Schaller, None; A.H. Wolf, None; U.C. Welge Luessen, None; A.J. Mueller, None; A. Kampik, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1203. doi:
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      U.C. Schaller, A.H. Wolf, U.C. Welge Luessen, A.J. Mueller, A. Kampik; Detection of Angiostatin and Endostatin in Human Uveal Melanoma . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1203.

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Abstract

Abstract: : Purpose: This study examined the ability of human uveal melanomas to produce the anti–angiogenic factors Angiostatin and Endostatin. Methods: Parafin embedded tissue from 7 uveal melanomas and 1 extrascleral part of an uveal melanoma was immunostained for angiostatin and endostatin using specific antibodies. Tumors were either spindle cell or mixed type melanomas. Staining for Angiostatin and Endostatin was graded. Results: Expression of Endostatin was found in 75%, while as staining for Angiostatin could be detected merely in 37%. Interestingly, Angiostatin was never found expressed selectively, while Endostatin could be detected alone in 37%. No expression of any of these factors was found in 2 cases (25%). There was no correlation to cell type. Conclusion: Angiogenesis is a critical component of tumorgenesis and metastasis The examined angiogenetic factors have been shown to play a significant role in inhibiting the development of distant metastasis. Our data demonstrate a positive but differing expression of the investigated anti–angiogenic substances Angiostatin and Endostatin in uveal melanomas. This differing expression of Endostatin and Angiostatin may correlate to the probability of developing systemic metastasis.

Keywords: immunohistochemistry • melanoma • oncology 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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