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U.C. Schaller, A.H. Wolf, U.C. Welge Luessen, A.J. Mueller, A. Kampik; Detection of Angiostatin and Endostatin in Human Uveal Melanoma . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1203.
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Purpose: This study examined the ability of human uveal melanomas to produce the anti–angiogenic factors Angiostatin and Endostatin. Methods: Parafin embedded tissue from 7 uveal melanomas and 1 extrascleral part of an uveal melanoma was immunostained for angiostatin and endostatin using specific antibodies. Tumors were either spindle cell or mixed type melanomas. Staining for Angiostatin and Endostatin was graded. Results: Expression of Endostatin was found in 75%, while as staining for Angiostatin could be detected merely in 37%. Interestingly, Angiostatin was never found expressed selectively, while Endostatin could be detected alone in 37%. No expression of any of these factors was found in 2 cases (25%). There was no correlation to cell type. Conclusion: Angiogenesis is a critical component of tumorgenesis and metastasis The examined angiogenetic factors have been shown to play a significant role in inhibiting the development of distant metastasis. Our data demonstrate a positive but differing expression of the investigated anti–angiogenic substances Angiostatin and Endostatin in uveal melanomas. This differing expression of Endostatin and Angiostatin may correlate to the probability of developing systemic metastasis.
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