Abstract
Abstract: :
Purpose: To examine the cell proliferation–related molecules in human uveal melanoma. Methods: Deparaffinized sections were processed for immunofluorescence immunohistochemistry. Antibodies against cyclin D1, c–Fos, c–Jun, phospho–c–Jun, PCNA, Erk, phospho–Rb protein were examined. Results: Cell proliferation–related molecules, i. e., cyclin D1, c–Fos, c–Jun, phospho–c–Jun, Erk and phospho–Rb protein, were all detected in melamona cells in association of cell proliferation. Phosphorylation of c–Jun indicated the activation of AP–1(activater protein–1) pathway. Conclusions: Cells in uveal melanoma express cell proliferation markers in their nuclei, indicating tumor cells are under a complex cell proliferation machinery. Phosphorylation of c–Jun indicates the activation of AP–1 cascade.
Keywords: melanoma • proliferation • oncology