May 2004
Volume 45, Issue 13
ARVO Annual Meeting Abstract  |   May 2004
Author Affiliations & Notes
  • C.–N. Kebache
    Department of Biology,
    Univ of Montreal, Montreal, PQ, Canada
  • M.–L. Garon
    School of Optometry,
    Univ of Montreal, Montreal, PQ, Canada
  • M. Rufiange
    Chronobiology Laboratory, Sacre–Coeur Hospital,
    Univ of Montreal, Montreal, PQ, Canada
  • C. Casanova
    School of Optometry,
    Univ of Montreal, Montreal, PQ, Canada
  • M. Hebert
    Department of Ophthalmology, Univ Laval, Quebec, PQ, Canada
  • P. Lachapelle
    Dep. of Neurology–Neurosurgery and Ophthalmology, McGill Univ–Montreal Children's Hosp Research Inst, Montreal, PQ, Canada
  • Footnotes
    Commercial Relationships  C. Kebache, None; M. Garon, None; M. Rufiange, None; C. Casanova, None; M. Hebert, None; P. Lachapelle, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 795. doi:
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      C.–N. Kebache, M.–L. Garon, M. Rufiange, C. Casanova, M. Hebert, P. Lachapelle; OVULATION ENHANCES THE PHOTOPIC ERG IN WOMEN . Invest. Ophthalmol. Vis. Sci. 2004;45(13):795.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: Animal experiments suggest that estrogen can enhance (acute effect) or suppress (chronic effect) the ERG. Can this be demonstrated in normally cycling women? Methods: Photopic (flashes:–0.80 to 2.84 log cd.s.m–2; background 30 cd. m–2) and scotopic (flashes: –3.21 to 0.39 log cd.s.m–2; 30 minutes of dark–adaptation) ERGs were obtained from normally cycling (not on oral contraceptives) women (N=5; 18–22 years old). Time of ovulation was determined with the Clear Plan® fertility monitor. Subjects were tested 4 times, on two consecutive cycles, as follows: follicular phase (5–7 days after onset of menses), ovulation (2 consecutive days as per Clear Plan® readings) and luteal phase (2–8 days prior to onset of the next cycle). Data was compared to that obtained from age–matched male subjects (2 recording sessions 1 week apart). Results: As previously reported, female ERGs are significantly larger than males’(average: 25% larger). Male ERGs did not demonstrate significant intersession variability. In contrast, the photopic responses (Vmax but not retinal sensitivity k) of women obtained on the two sessions closest to ovulation were always equally larger (10–15%) than follicular and luteal measurements which were not significantly different from each other. Interestingly, the scotopic responses (Vmax and retinal sensitivity k) did not demonstrate a similar trend. Conclusions: The small (but reproducible from cycle to cycle) enhancement of the photopic ERG at ovulation (where plasmatic estrogen peaks) is compatible with our animal results. While the photopic (cone) specificity of this effect remains to be elucidated, it could have a significant impact in responses soliciting more specifically (than full–field conditions) smaller population of cones (i.e. S–cone ERGs or multifocal ERGs) or in the diagnosis or follow–up of cone disorders. Consequently as a precautionary measure, clinical ERG data files should include the date of last menstruation. Supported by CIHR and FRSQ Réseau–Vision.

Keywords: electroretinography: non–clinical • clinical laboratory testing • retina 

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