Abstract
Abstract: :
Purpose:To evaluate performance of Optical Coherence Tomography (OCT) for discriminating eyes with early glaucoma from glaucoma suspects. Methods: 61 eyes of 36 patients diagnosed as glaucoma suspects (GS) or early glaucoma patients were selected form the database of the Glaucoma Division at Jules Stein Eye Institute, UCLA. Early glaucoma by disc (EGD) was defined as presence of focal disc damage or c/d asymmetry > 0.2. Glaucoma suspects were defined as presence of a large c/d ratio without the above characteristics. All patients had normal achromatic visual fields. Average nerve fiber layer thickness (NFLT) and NFLT in each of 4 quadrants and 12 clock hour sectors were compared between the two groups. ROC curves were used to assess the discriminating power of the STRATUS OCT. Results: Thirty–one glaucoma suspect and 30 EGD eyes were included. Average (± SD) NFLT was 98.7 ± 11.2 and 85.5 ± 16.4 microns in GS and EGD eyes, respectively (p < 0.001). A significant difference between the two groups was also found in the following quadrants and clock hour sectors: superior, nasal, and inferior quadrants and 11, 12, 1, 2, 3, and 6 o’clock sectors (p < 0.03 for each comparison). The NFLT at 1, 12, and 11 o’clock sectors had the highest areas under the ROC curve for discriminating the EGD group from the GS group (0.785, 0.734, and 0.729, respectively). Conclusions:The OCT discriminates well between glaucoma suspects and eyes with early glaucomatous disc damage with normal achromatic visual fields.
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)