May 2004
Volume 45, Issue 13
ARVO Annual Meeting Abstract  |   May 2004
Author Affiliations & Notes
  • S. Mosaed
    Ophthalmology, UC San Diego, La Jolla, CA
  • J.H. K. Liu
    Ophthalmology, UC San Diego, La Jolla, CA
  • R.N. Weinreb
    Ophthalmology, UC San Diego, La Jolla, CA
  • Footnotes
    Commercial Relationships  S. Mosaed, None; J.H.K. Liu, None; R.N. Weinreb, None.
  • Footnotes
    Support  NIH Grant EY07544
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 950. doi:
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      S. Mosaed, J.H. K. Liu, R.N. Weinreb; PREDICTING PEAK NOCTURNAL IOP DURING DAYTIME OFFICE HOURS IN GLAUCOMA PATIENTS . Invest. Ophthalmol. Vis. Sci. 2004;45(13):950.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose:To evaluate the correlation between in–office intraocular pressure (IOP) measurements to peak 24–hour IOP in a group of healthy and glaucomatous eyes. Methods:Thirty–three younger healthy individuals (age 18–25), 30 older healthy individuals (age 40–74), and 35 older glaucoma patients (age 41–79) were housed in a sleep laboratory for 24 hours. IOP of the right eye was measured every two hours in the sitting and supine positions during the diurnal period, and in the supine position only during the nocturnal period (11 PM to 7 AM) using a pneumatonometer. Results:The mean office hour (9:30 AM to 3:30 PM) supine IOP measurements were found to have the strongest correlation with peak nocturnal IOP in glaucomatous eyes (r=0.713, p<0.001) whereas this association was not as strong with older healthy eyes (r=0.534, p<0.01) or younger healthy eyes (r=0.224, p=0.21). The correlation between the office sitting IOP with the maximal supine nocturnal IOP elevation was moderate in younger healthy eyes (r=0.623, p<0.001) and in older glaucomatous eyes (r=0.566, p<0.001), but poor in older healthy eyes (r=0.229, p=0.223). Conclusions:The magnitude of nocturnal IOP peak in glaucomatous eyes can be predicted during routine office visits, using a modification of the current diurnal curve, where the better measurements are taken supine rather than in the sitting position. This method may provide the clinician with valuable information regarding the nocturnal IOP profile in glaucoma patients.

Keywords: intraocular pressure • circadian rhythms • clinical (human) or epidemiologic studies: risk factor assessment 

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