May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Frequency of glaucoma in patients with blepharospasm
Author Affiliations & Notes
  • A.G. B. Nicoletti
    Ophthalmology, São Paulo University, São Paulo, Brazil
  • L.C. Zacharias
    Ophthalmology, São Paulo University, São Paulo, Brazil
  • R.M. Vessani
    Ophthalmology, São Paulo University, São Paulo, Brazil
  • S. Matayoshi
    Ophthalmology, São Paulo University, São Paulo, Brazil
  • R. Susanna Jr
    Ophthalmology, São Paulo University, São Paulo, Brazil
  • Footnotes
    Commercial Relationships  A.G.B. Nicoletti, None; L.C. Zacharias, None; R.M. Vessani, None; S. Matayoshi, None; R. Susanna Jr, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 951. doi:
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      A.G. B. Nicoletti, L.C. Zacharias, R.M. Vessani, S. Matayoshi, R. Susanna Jr; Frequency of glaucoma in patients with blepharospasm . Invest. Ophthalmol. Vis. Sci. 2004;45(13):951.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:Forced eyelid closure can lead to intraocular pressures of 50 to 90 mmHg in normal eyes. This study was performed to evaluate the IOP and prevalence of glaucoma in patients with blepharospasm. Methods:Prospective consecutive study of 20 patients with blepharospasm diagnosis under clinical treatment with botulinum toxin and 19 control subjects with other eyelid abnormalities examined in the Ocular Plastic Surgery Service. Isolated IOP measurement, water drinking test (WDT) and prevalence of glaucoma were evaluated in both groups after botulinum toxin treatment. Results:Patients with blepharospasm had a mean period without botulinum toxin treatment (mean ± SD) of 3.63 ± 3.73 years. There was no significant difference in age, sex or race between groups. There was a significant difference in mean intraocular pressure between patients with blepharospasm and controls (15.83 ± 4.95 mmHg and 13.92 ± 2.48 mmHg, respectively p = 0.03). IOP peak and absolute IOP variation in the WDT were significantly higher in patients with blepharospasm compared to controls (19.50 ± 5.43 mmHg versus 16.53 ± 2.77 mmHg, p = 0.004 and 4.61 ± 2.50 mmHg versus 2.68 ± 1.38 mmHg, p < 0.0001, respectively). Glaucoma was diagnosed in 5 patients (26.31%) with blepharospasm and in one subject (5.26%) of the control group. Conclusions:Higher IOPs and a higher prevalence of glaucoma were observed in patients with blepharospasm. Careful glaucoma evaluation should be performed when examining those patients.

Keywords: clinical (human) or epidemiologic studies: prevalence/incidence • intraocular pressure • outflow: trabecular meshwork 
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