May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Non invasive evaluation of pigment dispersion syndrome using dynamic light scattering.
Author Affiliations & Notes
  • L. Pollonini
    National Center for Microgravity Research on Fluids and Combustion, NASA Glenn Research Center, Cleveland, OH
  • R.R. Ansari
    National Center for Microgravity Research on Fluids and Combustion, NASA Glenn Research Center, Cleveland, OH
  • A. Pasquali
    Department of Information Engineering, University of Modena and Reggio Emilia, Modena, Italy
  • L. Rovati
    Department of Information Engineering, University of Modena and Reggio Emilia, Modena, Italy
  • L. Quaranta
    Eye Clinic, University of Brescia, Brescia, Italy
  • Footnotes
    Commercial Relationships  L. Pollonini, None; R.R. Ansari, None; A. Pasquali, None; L. Rovati, None; L. Quaranta, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 959. doi:
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      L. Pollonini, R.R. Ansari, A. Pasquali, L. Rovati, L. Quaranta; Non invasive evaluation of pigment dispersion syndrome using dynamic light scattering. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):959.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: The goal of this pilot study is to evaluate patients affected by pigment dispersion syndrome (PDS) using the technique of dynamic light scattering (DLS) in the aqueous humor (AH). Methods: Dynamic light scattering is a technique able to detect abnormalities at molecular level in ocular tissues. DLS particle size measurements are performed in the AH. 16 patients affected with PDS (16 eyes; mean age: 53.3±14.1; gender: 8 male, 8 female) and 15 normal subjects (15 eyes; mean age: 64.1±15.2; gender: 3 male, 12 female) were evaluated for the study. Results: The measuring range of diameter is between 50 and 2000 nm. The mean diameter of particles in PDS eyes was found to be 761±638 nm, whilst in normal eyes was 135±193 nm (t–Student test: P=0.009). DLS measurements showed a significantly higher prevalence of particles with a mean diameter under 500nm in normal eyes when compared with PDS eyes (93.3% normal eyes vs 47% in PDS eyes; Fisher’s exact test: P=0.013). Conclusions: Larger size particles were detected in PDS eyes compared with normal cohorts. DLS can be used to detect pigment dispersion syndrome non invasively.

Keywords: clinical (human) or epidemiologic studies: systems/equipment/techniques • aqueous 
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