May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Prospective multi–center trial of long–term intraocular pressure (IOP) change following phacoemulsification cataract extraction (PCE) in patients with and without pseudoexfoliation (PEX)
K.F. Damji; A.G. P. Konstas; J.M. Liebmann; W.G. Hodge; N.G. Ziakas; S. Giannikakis; G. Mintsioulis; A. Merkur; Y.I. Pan; R. Ritch
Author Affiliations & Notes
  • K.F. Damji
    Ophthalmology, University of Ottawa Eye Institute, Ottawa, ON, Canada
  • A.G. P. Konstas
    Ophthalmology, Aristotle University, Thessaloniki, Greece
  • J.M. Liebmann
    Ophthalmology, New York Eye and Ear Infirmary, New York, NY
  • W.G. Hodge
    Ophthalmology, University of Ottawa Eye Institute, Ottawa, ON, Canada
  • N.G. Ziakas
    Ophthalmology, Aristotle University, Thessaloniki, Greece
  • S. Giannikakis
    Ophthalmology, Aristotle University, Thessaloniki, Greece
  • G. Mintsioulis
    Ophthalmology, University of Ottawa Eye Institute, Ottawa, ON, Canada
  • A. Merkur
    Ophthalmology, University of Ottawa Eye Institute, Ottawa, ON, Canada
  • Y.I. Pan
    Ophthalmology, University of Ottawa Eye Institute, Ottawa, ON, Canada
  • R. Ritch
    Ophthalmology, New York Eye and Ear Infirmary, New York, NY
  • Footnotes
    Commercial Relationships  K.F. Damji, None; A.G.P. Konstas, None; J.M. Liebmann, None; W.G. Hodge, None; N.G. Ziakas, None; S. Giannikakis, None; G. Mintsioulis, None; A. Merkur, None; Y.I. Pan, None; R. Ritch, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 968. doi:
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      K.F. Damji, A.G. P. Konstas, J.M. Liebmann, W.G. Hodge, N.G. Ziakas, S. Giannikakis, G. Mintsioulis, A. Merkur, Y.I. Pan, R. Ritch; Prospective multi–center trial of long–term intraocular pressure (IOP) change following phacoemulsification cataract extraction (PCE) in patients with and without pseudoexfoliation (PEX) . Invest. Ophthalmol. Vis. Sci. 2004;45(13):968.

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Abstract

Abstract: : Purpose: To determine the long–term IOP response to PCE in patients with PEX and appropriate controls. Methods: Prospective multi–center cohort study with the following inclusion criteria: age greater than 50, open angle, and cataract. Two groups were enrolled – those with PEX and those without. The main outcome was IOP change at 1 and 2 yrs vs. preoperative IOP. Univariate and multivariate analyses were performed. Results: 183 eyes were enrolled, 71 with PEX and 112 without PEX. There were 29 eyes with glaucoma in both groups. Baseline variables were similar but the PEX group did have significantly higher mean baseline IOP compared to non PEX (17.60 + 3.23 vs. 16.08 + 3.18 mm Hg, p=0.002).  

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IOP reduction is greater in the PEX group, but there seems to be a trend of decreasing significance for this effect. Furthermore, multivariate analysis demonstrated that the IOP lowering effect in the PEX group is largely due to irrigation volume at the time of surgery. There is a significant correlation between greater volume of irrigation used and greater IOP reduction at 1 year (r = 0.43; p=0.005) and 2 years (r = 0.34; p=0.023) post–op, but not in the non PEX group (1 year: r = 0.10; p=0.49; 2 years: r = 0.13; p= 0.35). The percentage of patients with a post–op IOP spike (> 6 mm Hg) was similar and relatively high in both PEX and non PEX groups (34% vs. 25%; p=0.54) but this had settled by 6 wks. Conclusion:IOP decreases significantly following phacoemulsification in eyes with PEX vs. controls. This effect persists for at least two years in this study, although it diminishes with time. The decrease in IOP in patients with PEX is proportional to irrigation volume used at the time of surgery. Acknowledgments: Lindberg Society and Anuj Bhargava for assistance with the protocol. Sophia Chaudry, Hamidah Meghani, Yasmin Ladak, and Amy Bovell assisted in data tabulation.

Keywords: intraocular pressure • cataract 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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