May 2004
Volume 45, Issue 13
ARVO Annual Meeting Abstract  |   May 2004
Rod photoreceptor and post receptoral response in ROP rats
Author Affiliations & Notes
  • K. Liu
    Ophthalmology, Children's Hospital, Boston, MA
  • C. Falk
    Ophthalmology, Children's Hospital, Boston, MA
  • M. Youssef
    Ophthalmology, Children's Hospital, Boston, MA
  • R.M. Hansen
    Ophthalmology, Children's Hospital, Boston, MA
  • A.B. Fulton
    Ophthalmology, Children's Hospital, Boston, MA
  • Footnotes
    Commercial Relationships  K. Liu, None; C. Falk, None; M. Youssef, None; R.M. Hansen, None; A.B. Fulton, None.
  • Footnotes
    Support  Massachusetts Lions Eye Research Foundation
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1354. doi:
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      K. Liu, C. Falk, M. Youssef, R.M. Hansen, A.B. Fulton; Rod photoreceptor and post receptoral response in ROP rats . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1354.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: Conduct a longitudinal investigation of rod photoreceptor and post–receptoral function in rats with oxygen induced retinopathy ("ROP rats"), a model of human retinopathy of prematurity. Methods: Retinopathy was induced using the oxygen exposures recommended by Penn. Starting at age 16 days, and thereafter at approximately weekly intervals, ERG responses to a 6+ log unit range of full–field stimuli were recorded from dark adapted, lightly anesthetized rats. Rod cell sensitivity (SROD) and saturated response amplitude (RROD) were calculated by fit of a model of the activation of phototransduction to the ERG a–wave. Postreceptoral responses were evaluated by analysis of ERG b–wave stimulus/response functions; saturated b–wave amplitude (Vmax) and b–wave sensitivity (1/σ) were calculated. Results: In ROP rats, SROD and RROD were lower than in controls at all ages, but showed modest developmental increases; the deficits in SROD predict deficits in post receptoral sensitivity. In control rats, both receptoral and post receptoral response parameters showed developmental increases. Conclusions: In contrast to the resolution of the vascular abnormalities (Falk et al.), retinal dysfunction persists long after the ROP inducing exposure, and is present in mature retina just as in children with mild ROP. In ROP rats, as in human ROP subjects, rod function predicts post–receptoral function

Keywords: electroretinography: non–clinical • retinopathy of prematurity • photoreceptors 

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