May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
AQuifyTM MPS: Novel Multifunctional Contact Lens Care System
Author Affiliations & Notes
  • M.F. Mowrey–McKee
    CIBA Vision Corporation, A Novartis Company, Duluth, GA CIBA Vision Corporation, A Novartis Company, Duluth, GA
  • C. Amos
    CIBA Vision Corporation, A Novartis Company, Duluth, GA CIBA Vision Corporation, A Novartis Company, Duluth, GA
    Toxicology / Microbiology,
  • A. Sills
    CIBA Vision Corporation, A Novartis Company, Duluth, GA CIBA Vision Corporation, A Novartis Company, Duluth, GA
    Toxicology / Microbiology,
  • S. Lambert
    CIBA Vision Corporation, A Novartis Company, Duluth, GA CIBA Vision Corporation, A Novartis Company, Duluth, GA
    Toxicology / Microbiology,
  • M. George
    CIBA Vision Corporation, A Novartis Company, Duluth, GA CIBA Vision Corporation, A Novartis Company, Duluth, GA
    Toxicology / Microbiology,
  • M. Ajello
    CIBA Vision Corporation, A Novartis Company, Duluth, GA CIBA Vision Corporation, A Novartis Company, Duluth, GA
    Toxicology / Microbiology,
  • K. Lindley
    CIBA Vision Corporation, A Novartis Company, Duluth, GA CIBA Vision Corporation, A Novartis Company, Duluth, GA
    Toxicology / Microbiology,
  • Footnotes
    Commercial Relationships  M.F. Mowrey–McKee, CIBA Vision Corporation E; C. Amos, CIBA Vision Corporation E; CIBA Vision Corporation E; A. Sills, CIBA Vision Corporation E; S. Lambert, CIBA Vision Corporation E; M. George, CIBA Vision Corporation E; M. Ajello, CIBA Vision Corporation E; K. Lindley, CIBA Vision Corporation E.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1540. doi:
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    • Get Citation

      M.F. Mowrey–McKee, C. Amos, A. Sills, S. Lambert, M. George, M. Ajello, K. Lindley; AQuifyTM MPS: Novel Multifunctional Contact Lens Care System . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1540.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: AQuifyTM MPS, a novel multipurpose contact lens care disinfecting solution, and the MicroBlockTM Antimicrobial Lens Case were evaluated for cytotoxicity, antimicrobial activity and clinical performance. Methods: AQuifyTM MPS and competitive multipurpose solutions were evaluated for cytotoxicity using a modified USP Elution Test, for antimicrobial activity per ISO 14729, and for clinical performance three contralateral clinicals using no rub regimens. The AQuifyTM MPS MicroBlockTM lens case was evaluated for antimicrobial activity per ASTM Method E2149–01. Results: AQuifyTM MPS, SOLO–careR PLUS, COMPLETER Moisture PLUSTM and ReNu MultiPlusR were noncytotoxic, whereas OptiFreeR ExpressR was cytotoxic. All of the solutions met primary criteria of the Stand Alone Test for antimicrobial activity. In a one–month trial of 37 subjects, AQuifyTM MPS had less corneal staining and greater overall comfort at one month over current SOLO–careR PLUS. In a two–month contralateral trial of 80 subjects, AQuifyTM MPS was preferred by 2:1 or more over ReNu MultiPlusR for those subjects with a preference at all visits throughout the study. A three–month contralateral trial with 66 subjects was conducted versus COMPLETER Moisture PLUSTM. After one month subjects strongly agreed with statements such as "lasting comfort", "helped prevent my lenses from feeling dried out" and "made my lenses feeling comfortable until the end of my lens wearing day" for the AQuifyTM MPS eye. After 3 months of use AQuifyTM MPS was preferred by 18:11 over COMPLETER Moisture PLUSTM for those subjects with a preference. The MicroBlockTM lens case resulted in significant reductions for all four challenge organisms (Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Serratia marcescens). Conclusions: The AQuifyTM MPS lens care system addresses patient needs by effectively killing microorganisms, in reducing the incidence of corneal staining, in providing a comfortable lens–wearing experience, and by including a lens case that kills bacteria and thus may inhibit biofilm formation.

Keywords: contact lens • clinical (human) or epidemiologic studies: outcomes/complications 
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