May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Morphologic Changes in Cat Epithelium Following Overnight Lens Wear with the Paragon CRT Lens for Corneal Reshaping
Author Affiliations & Notes
  • J.D. Choo
    College of Optometry, Pacific University, Forest Grove, OR
  • P.J. Caroline
    College of Optometry, Pacific University, Forest Grove, OR
  • D.D. Harlin
    College of Optometry, Pacific University, Forest Grove, OR
  • W. Meyers
    Technology Development, Paragon Vision Sciences, Mesa, AZ
  • Footnotes
    Commercial Relationships  J.D. Choo, None; P.J. Caroline, Paragon Vision Sciences C, R; D.D. Harlin, None; W. Meyers, Paragon Vision Sciences E, P.
  • Footnotes
    Support  Paragon Vision Sciences
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1552. doi:
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      J.D. Choo, P.J. Caroline, D.D. Harlin, W. Meyers; Morphologic Changes in Cat Epithelium Following Overnight Lens Wear with the Paragon CRT Lens for Corneal Reshaping . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1552.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:Corneal reshaping with contact lenses (orthokeratology) has been found to be a safe and effective technique in correcting patients with low to moderate degrees of myopia. At this time, the exact forces and mechanisms responsible for the topographical changes seen in overnight corneal reshaping are poorly understood. This study was undertaken to better understand how the procedure works and exactly which corneal tissues are involved in the process. Methods:Thirteen cats of the same age, gender, species and weight were used in this study. One animal served as a control with no lens wear. The remaining 12 animals were fitted with specially designed Paragon CRT lenses for the correction of myopia in the right eye and hyperopia in the left eye. The lenses were worn for periods of 4, 8, 24 and 48 hours and 7 and 14 days. The animals were euthanised at the above scheduled time periods and the corneal tissue stained with H&E, PAS and Alcian Blue for histologic evaluation and measurement. Five measurements of epithelial thickness were taken with the Image Pro–Plus Measurement Software and averaged. Results:The control eyes revealed an average central epithelial thickness of 37.65 microns and mid–peripherally, 3.0 mm from centre of 37.89 microns. The right eyes of the animals (fitted for the correction of myopia) showed a progressive central thinning from 34.08 microns at 4 hours to 11.85 microns at 14 days. Over the same time period, there was a subsequent thickening of the mid–peripheral epithelium from 49.61 microns at 4 hours to 55.20 microns at 14 days. The left eyes (fitted for the correction of hyperopia) showed progressive thickening of the central epithelium from 58.03 microns at 4 hours to 80.86 microns at 14 days and progressive mid–peripheral thinning from 42.75 at 4 hours to 13.02 at 14 days. Conclusions:The results of this study show a progressive, time related change in epithelial thickness associated with the wearing of the Paragon CRT lenses for overnight corneal reshaping. Eyes wearing lenses for the correction of myopia showed significant central epithelial thinning with a proliferation of cells mid–peripherally. Eyes wearing lenses for the correction of hyperopia showed the opposite pattern with central epithelial thickening and mid–peripheral thinning. Further ultra–structure studies will be necessary to determine the exact mechanism of these changes. Additionally, further research into the role of stromal restructuring will need to be investigated.

Keywords: contact lens • cornea: epithelium 
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