May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Corneal Thickness changes after one year of hydrogel contact lens use.
Author Affiliations & Notes
  • M.J. Gonzalez–Garcia
    IOBA, Valladolid, Spain
  • D.J. Galarreta
    IOBA, Valladolid, Spain
  • I. Arranz
    IOBA, Valladolid, Spain
  • A. Mayo
    IOBA, Valladolid, Spain
  • M. Calonge
    IOBA, Valladolid, Spain
  • J.M. Herreras
    IOBA, Valladolid, Spain
  • Footnotes
    Commercial Relationships  M.J. Gonzalez–Garcia, None; D.J. Galarreta, None; I. Arranz, None; A. Mayo, None; M. Calonge, None; J.M. Herreras, None.
  • Footnotes
    Support  FIS–01/0185
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1571. doi:
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      M.J. Gonzalez–Garcia, D.J. Galarreta, I. Arranz, A. Mayo, M. Calonge, J.M. Herreras; Corneal Thickness changes after one year of hydrogel contact lens use. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1571.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To evaluate the effect of one year of high and low water content hydrogel contact lens (HCL) use in corneal thickness. Methods: Sixty healthy myopic subjects (120 eyes) between 18 and 35 years of age who had never worn contact lenses before were randomly fitted with low –38%– (group I: 62 subjects) and high –66%– (group II: 58 subjects) water content HCL. Evaluation of corneal thickness with Ultrasound Pachymetry (UP) was performed before (baseline) and after 1, 3, 6, and 12 months of HCL use, as well as 15 days after HCL discontinuation. Measures were taken at the central, inferior, superior, nasal and temporal areas of the cornea. Differences in corneal thickness in the different visits in both groups and between groups were evaluated. Results: Baseline data (mean+/–SE) for the different corneal areas were: Group I= central 556.7+/–3.4 µm; inferior 706.0+/–6.0 µm; superior 683.9+/–4.5µm; nasal 695+/–5µm; and temporal cornea 698.7+/–6µm. Group II= central 542.8+/–3.4µm; inferior 695.7+/–6.2µm; superior 675.8+/–5.4µm; nasal 680+/–6.2µm; and temporal cornea 689.3+/–6.1µm. In both groups, all measurements increased compared to baseline, being significant centrally (2.3µm, p<0.05) and nasally (10.9µm, p<0.05) at 1 month and in superior measure (8.2µm, p<0.01) at three months in group I. In group II there was a significant increase in nasal measure at 1 month (11.8µm, p<0.05). A decrease was found in all measurements after 15 days of discontinuation when compared with 12 months of use, statistically significant for group I in central (–7.2µm, p<0.01), inferior (–19.3µm, p<0.01), nasal (–12.9µm, p<0.01) and temporal measures (–12.1µm, p<0.05). No statistically differences were found for group II measures. When comparing baseline with 15 days of HCL discontinuation measures, a decrease trend was found for both groups in all measures. These differences were statistically significant for group I in central (8.8µm, p<0.01) and nasal (12.7µm, p<0.01) measures and for group II in central (2.6µm, p<0.05) and superior (7.3µm, p<0.01) measures.When comparing baseline with 15 days of HCL discontinuation measures, a decrease trend was found for both groups in all measures. These differences were statistically significant for group I in central (8.8µm, p<0.01) and nasal (12.7µm, p<0.01) measures and for group II in central (2.6µm, p<0.05) and superior (7.3µm, p<0.01) measures. Conclusions: Low water content HCL use initially causes a significant increase in corneal thickness, not found with high water content HCL. A decrease in corneal thickness is observed in group I when HCL use is discontinued after 12 months of use. These results seem to advise the use of high water content HCL over that low water HCL.

Keywords: contact lens • cornea: clinical science • cornea: epithelium 
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