May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Autoimmune Retinopathy in Multiple Sclerosis: A Pilot Study
M. Sproule; F. Forooghian; P. O'Connor; L. Gordon; G. Jirawuthiworavong; C. Westall
Author Affiliations & Notes
  • M. Sproule
    Ophthalmology, University of Toronto and Hospital for Sick Children, Toronto, ON, Canada
  • F. Forooghian
    Ophthalmology, University of Toronto, Toronto, ON, Canada
  • P. O'Connor
    Neurology, University of Toronto and St. Michael's Hospital, Toronto, ON, Canada
  • L. Gordon
    Jules Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
    Ophthalmology, Greater Los Angeles VA Healthcare System, Los Angeles, CA
  • G. Jirawuthiworavong
    Jules Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
  • C. Westall
    Ophthalmology, University of Toronto and Hospital for Sick Children, Toronto, ON, Canada
  • Footnotes
    Commercial Relationships  M. Sproule, None; F. Forooghian, None; P. O'Connor, None; L. Gordon, None; G. Jirawuthiworavong, None; C. Westall, None.
  • Footnotes
    Support  The Multiple Sclerosis Society of Canada Grant
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1592. doi:
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      M. Sproule, F. Forooghian, P. O'Connor, L. Gordon, G. Jirawuthiworavong, C. Westall; Autoimmune Retinopathy in Multiple Sclerosis: A Pilot Study . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1592.

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Abstract

Abstract: : Purpose:Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system involving axon demyelination and destruction. Whether MS involves an immune attack on the retina is yet to be determined. The purpose of this study is to determine if the electroretinogram (ERG) is affected in patients with MS compared with controls. The primary outcome measure is sensitivity (S) of the rod response. This study is part of a wider study investigating the correlation between retinal function and retinal antibody testing. Methods:Study participants with MS were recruited from the MS clinic at St. Michael’s Hospital. Control participants were individuals with no neurological or ophthalmology disease of the same sex and age as the participants. An electroretinogram (ERG) was recorded according to ISCEV standards. An additional bright flash scotopic response determined S and Rm of the rod receptor activity (Hood and Birch, Doc Ophthalmol. 1986). The pupils were dilated and a conductive recording DTL fiber was placed across the eye. Thirty Hz flicker and oscillatory potential responses allowed for assessment of middle and inner retina processing. Results: Twenty–eight patients with MS (average age 41) and twenty–seven control subjects (average age 33) have been tested. Independent t–test reveals a statistically significant difference in sensitivity of the a–wave response to a single bright flash (p=0.05). There were also differences in oscillatory potential amplitude (p=0.025), cone b–wave implicit time (p=0.013) and flicker implicit time (p=0.016) between patient and control groups. Conclusion:Differences in ERG responses are observed in patients with MS as compared with age matched controls. Some of these differences, such as the bright flash rod response, cannot be explained on the basis of retrograde transynaptic degeneration of the inner nuclear layer secondary to optic atrophy. These differences may occur as a result of autoimmune retinopathy. Serum antiretinal antibody titres, and their correlation to ERG responses, are currently being assessed.

Keywords: electroretinography: clinical • autoimmune disease • electrophysiology: clinical 
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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