May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
Herpes Simplex Virus Entry Receptor Nectin–1 is Widely Expressed in Murine Trigeminal Ganglion and Brain Tissue.
Author Affiliations & Notes
  • P.M. Scanlan
    Ophthalmology/Visual Sciences and Microbiology/Immunology,
    University Illinois–Chicago, Chicago, IL
  • V. Tiwari
    Ophthalmology/Visual Sciences and Microbiology/Immunology,
    University Illinois–Chicago, Chicago, IL
  • C. Clement
    Ophthalmology/Visual Sciences and Microbiology/Immunology,
    University Illinois–Chicago, Chicago, IL
  • V. Sheth
    Ophthalmology/Visual Sciences,
    University Illinois–Chicago, Chicago, IL
  • D. Shukla
    Ophthalmology/Visual Sciences and Microbiology/Immunology,
    University Illinois–Chicago, Chicago, IL
  • T. Valyi–Nagy
    Pathology,
    University Illinois–Chicago, Chicago, IL
  • Footnotes
    Commercial Relationships  P.M. Scanlan, None; V. Tiwari, None; C. Clement, None; V. Sheth, None; D. Shukla, None; T. Valyi–Nagy, None.
  • Footnotes
    Support  1K22 AI053836 (DS)
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1644. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      P.M. Scanlan, V. Tiwari, C. Clement, V. Sheth, D. Shukla, T. Valyi–Nagy; Herpes Simplex Virus Entry Receptor Nectin–1 is Widely Expressed in Murine Trigeminal Ganglion and Brain Tissue. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1644.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: The goals of this study were to determine whether nectin–1, a receptor for herpes simplex virus (HSV) entry and spread, is expressed in murine trigeminal ganglion (TG) and brain tissue and to determine whether HSV type 1 (HSV–1) infection has an effect on nectin–1 expression in these tissues. Methods: Nectin–1 and HSV–1 protein expression were determined by immunohistochemistry in TGs and brain tissue of untreated BALB/c mice and in nervous system tissues of mice euthanized 7 days or 7 months following corneal or intracerebral HSV–1 inoculation or mock infection. Results: In tissues derived from untreated and mock–infected mice, widespread nectin–1 expression was detected in the TG and brain. Expression was most prevalent among neurons, but many glial cells and vascular cells were also immunoreactive for nectin–1. HSV–1 infection did not lead to significant changes of nectin–1 expression in any of the tissues examined. Conclusions: The results indicate that nectin–1 is widely expressed in TG and brain tissues. The wide expression of nectin–1 suggests that it plays a significant role in viral cell entry and cell–to–cell spread during HSV–1 infection of the nervous system.

Keywords: immunohistochemistry • herpes simplex virus • receptors 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×