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E.G. Romanowski, T.L. Bowlin, K.A. Yates, F.S. Mah, Y.J. Gordon; Topical NMSO3 Inhibits Adenovirus Replication in the Ad5/NZW Rabbit Ocular Model. . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1657.
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Purpose: Following topical cidofovir’s failure in clinical development, the need for an antiviral to treat adenovirus (Ad) ocular infections persists. The goal of the current study was to determine the antiviral efficacy of NMSO3, a novel sulfated sialyl lipid antiviral agent, on acute adenovirus (Ad) replication in the Ad5/NZW rabbit ocular model. Methods: In two trials, a total of 30 NZW rabbits were topically inoculated in both eyes, following corneal scarification, with 1.5 x 106 pfu/eye of Ad5. On day 1, the rabbits were divided into 3 topical treatment groups (n=10/group): I – 10% NMSO3, 5 times daily for 7 days; II – 0.5% Cidofovir (CDV), twice daily for 7 days; III – Control (saline), 5 times daily for 7 days. All eyes were cultured for virus on days 0, 1, 3, 4, 5, 7, 9, 11, and 14. Results:
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