May 2004
Volume 45, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2004
The Correlation Between Erythrocyte Aldose Reductase Level And Human Diabetic Cataract
Author Affiliations & Notes
  • N. Oishi
    Ophthalmology, University of Fukui, Yoshida–gun, Fukui, Japan
  • S. Morikubo
    Ophthalmology, University of Fukui, Yoshida–gun, Fukui, Japan
  • E. Kubo
    Ophthalmology, University of Fukui, Yoshida–gun, Fukui, Japan
  • Y. Takamura
    Ophthalmology, University of Fukui, Yoshida–gun, Fukui, Japan
  • S. Tsuzuki
    Ophthalmology, University of Fukui, Yoshida–gun, Fukui, Japan
  • T. Tanimoto
    National Institute of Health Sciednces, Osaka, Japan
  • Y. Akagi
    Ophthalmology, University of Fukui, Yoshida–gun, Fukui, Japan
  • Footnotes
    Commercial Relationships  N. Oishi, None; S. Morikubo, None; E. Kubo, None; Y. Takamura, None; S. Tsuzuki, None; T. Tanimoto, None; Y. Akagi, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1702. doi:
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      N. Oishi, S. Morikubo, E. Kubo, Y. Takamura, S. Tsuzuki, T. Tanimoto, Y. Akagi; The Correlation Between Erythrocyte Aldose Reductase Level And Human Diabetic Cataract . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1702.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:We have reported that the prevalence of diabetic retinopathy increased with increased erythrocyte aldose reductase (AR) levels in type 2 diabetic patients with a duration of diabetes of less than 10 years (BJO 2002;86:1363–1366). From these observations, we suggested that the inhibition of AR in patients with early type 2 diabetic patients might be beneficial in reducing the development of diabetic retinopathy. On the other hand, it has been well established diabetes is highly significant risk factor for cataract. Previous reports concluded that major pattern of human diabetic cataract is cortical and posterior subcapsular cataract, especially appeared in relatively younger patients. In present study, we investigated the relationship between human diabetic cataract and AR. Methods:We evaluated the pattern of the cataract in diabetic patients who were treated at University of Fukui using LOCS classification. At the same time, blood samples were obtained from the patients. The erythrocyte AR levels were determined by ELISA technique. We investigated the relationship between erythrocyte AR levels and the prevalence of posterior subcapsular, nuclear and cortical cataracts in all diabetic patients and also in subgroups classified by age younger than 60 years old and diabetic duration lesser than 10 years using Spearman rank correlation coefficient. Results: The prevalence of posterior subcapsular cataract was significantly increased as AR level elevated in the relatively younger than 60 years old and earlier diabetic duration lesser 10 years diabetic patients, but not in total ones. There was no relationship between nuclear and cortical cataract and AR levels. Conclusions:It was found that AR levels influenced the prevalence of diabetic cataract in relatively younger and earlier diabetic patients. Therefore, it was suggested that the inhibition of AR in earlier diabetic patients was important for preventing the development of diabetic cataract.

Keywords: cataract • diabetes • pathology: human 
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