May 2004
Volume 45, Issue 13
ARVO Annual Meeting Abstract  |   May 2004
Author Affiliations & Notes
  • P.F. Kador
    Pharmaceutics, Ophthalmology and Pharmacology,
    University of Nebraska Medical Center, Omaha, NE
  • J. Inoue
    Kobe Creative Center, Senju Pharmaceutical Company, Kobe, Japan
  • K. Blessing
    University of Nebraska Medical Center, Omaha, NE
  • Footnotes
    Commercial Relationships  P.F. Kador, None; J. Inoue, None; K. Blessing, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1704. doi:
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    • Get Citation

      P.F. Kador, J. Inoue, K. Blessing; CAN SUGAR CATARACT FORMATION BE DELAYED INDEPENDENT OF ALDOSE REDUCTASE INHIBITION? . Invest. Ophthalmol. Vis. Sci. 2004;45(13):1704.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: : It is well established that the intralenticular accumulation of sorbitol initiates osmotic changes that start a biochemical cascade of events that result in sugar cataract formation and that aldose reductase inhibitors block the formation of these cataracts by inhibiting the intralenticular accumulation of sorbitol. The purpose of this study was to determine if sugar cataract formation can also be delayed by methods independent of inhibiting sorbitol accumulation. Methods: Two analogs of 4–[4–(N,N–dimethylsulfamoyl)piperazino]–2–methylpyrimidine were synthesized and their effect on cataract formation was examined by orally administering these agents to diabetic rats. Results: Neither synthesized analog displayed significant aldose reductase or sorbitol dehydrogenase inhibition; however, both analogs appeared to delay cataract formation in diabetic rats without reducing lens polyol formation or hyperglycemia – the major initiating factors of diabetic cataract formation. Conclusions: This study suggests that the progression of lens opacification in diabetic rats can be delayed independent of inhibiting sorbitol formation, the initiating source of cataract formation.

Keywords: cataract • drug toxicity/drug effects 

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